{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:08:52Z","timestamp":1781068132033,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To systematically evaluate the risk factors of early\u2010onset seizures after stroke, in order to better provide evidence\u2010based results for early detection, identification, targeted prevention, and treatment of this disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, EMBASE, The Cochrane Library, CNKI, and WanFang databases were searched to collect relevant studies on the risk factors of early\u2010onset seizures after stroke from January 2010 to January 2020. Meta\u2010analysis of all included studies was performed by using RevMan version 5.3 and Stata version 14.0 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighteen case\u2013control studies with a total sample size of 13,289 cases, including 813 cases with early\u2010onset seizures after stroke, and 12,476 cases with non\u2010early\u2010onset seizures after stroke were included. The results of meta\u2010analysis showed that cortical involvement [Odds Ratio (OR)\u00a0=\u00a05.00, 95%Confidence Interval (CI) (2.85, 8.74),\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.00001], cerebral infarction with hemorrhagic transformation [OR\u00a0=\u00a02.77, 95%CI (1.87, 4.11),\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.00001] and intracerebral hemorrhage [OR\u00a0=\u00a01.83, 95%CI (1.13, 2.97),\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01]\u2010related factors showed greater association with the occurrence of early\u2010onset seizures after stroke.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that cortical involvement, intracerebral hemorrhage, and cerebral infarction with hemorrhagic transformation are important predictors and risk factors for early seizures after stroke, while the patient's gender, age, NHISS score, alcoholism, smoking, high blood pressure, diabetes, atrial fibrillation, dyslipidemia, receiving surgical treatment, and reperfusion therapy showed no association with the occurrence of early\u2010onset seizures after stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2142","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T04:31:54Z","timestamp":1620102714000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Risk factors for early\u2013onset seizures after stroke: A systematicreview and meta\u2010analysis of 18 observational studies"],"prefix":"10.1002","volume":"11","author":[{"given":"Sitian","family":"Ma","sequence":"first","affiliation":[{"name":"Shaanxi University of Chinese Medicine Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0876-3091","authenticated-orcid":false,"given":"Xiaoxuan","family":"Fan","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Shaanxi University of Chinese Medicine Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Zhao","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Shaanxi University of Chinese Medicine Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Shaanxi University of Chinese Medicine Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[{"name":"Shaanxi University of Chinese Medicine Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Shaanxi University of Chinese Medicine Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2019.106549"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/1596-3519.126936"},{"issue":"3","key":"e_1_2_12_4_1","first-page":"715","article-title":"Early seizures in patients with acute stroke: frequency, predictive factors, and effect on clinical outcome","volume":"4","author":"Alberti A.","year":"2008","journal-title":"Vasc Health Risk Manag"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055498"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010115"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182364878"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12075"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.9.1363"},{"key":"e_1_2_12_10_1","unstructured":"Bian S.(2017).Incidence and predictive factors of early seizures and late seizures after stroke and correlation research between MRI and EEG. master's degree. 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