{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:24:11Z","timestamp":1787066651461,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:00:00Z","timestamp":1622592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2014CB846104"],"award-info":[{"award-number":["2014CB846104"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Most youths who suffer from post\u2010traumatic stress disorder (PTSD) lose their diagnosis in the first 1\u20132\u00a0years. However, there are few studies on this brain mechanism, and the heterogeneity of the findings is partially due to the different stimuli applied and the mixed trauma history. Therefore, the use of trauma\u2010related\/unrelated stimuli to study the remittance mechanism of earthquake\u2010induced PTSD could advance our knowledge of PTSD and inspire future treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirteen youths with PTSD, 18 remitted participants, and 18 control participants underwent functional magnetic resonance imaging (fMRI), while viewing trauma\u2010related pictures, trauma\u2010unrelated negative pictures, and scrambled pictures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Under trauma\u2010unrelated condition, the neural activity of the left hippocampus in the remitted group was between the two other groups. Under trauma\u2010related condition, the PTSD and the remitted group exhibited higher neural activity in the right middle occipital gyrus than controls. The remitted group showed higher neural activity in the right parahippocampal gyrus and right lingual gyrus under trauma\u2010related condition than trauma\u2010unrelated condition, while no significant difference was found in PTSD group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PTSD status\u2010related group differences are mainly reflected in the left hippocampus under the trauma\u2010unrelated condition, while the hyperactivity in the right middle occipital gyrus under trauma\u2010related condition could be an endophenotype for PTSD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2173","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T12:46:36Z","timestamp":1622637996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neural response to trauma\u2010related and trauma\u2010unrelated negative stimuli in remitted and persistent pediatric post\u2010traumatic stress disorder"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9320-1415","authenticated-orcid":false,"given":"Peng","family":"Wang","sequence":"first","affiliation":[{"name":"Sixth Hospital\/Institute of Mental Health Peking University Beijing China"},{"name":"National Clinical Research Center for Mental Disorders &amp; The Key Laboratory of Mental Health Ministry of Health (Peking University) Beijing China"},{"name":"Shenzhen Children's Hospital Shenzhen China"},{"name":"Cardiac Rehabilitation Center, Fuwai Hospital CAMS&amp;PUMC Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zu\u2010Lai","family":"Peng","sequence":"additional","affiliation":[{"name":"Sixth Hospital\/Institute of Mental Health Peking University Beijing China"},{"name":"National Clinical Research Center for Mental Disorders &amp; The Key Laboratory of Mental Health Ministry of Health (Peking University) Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[{"name":"Sixth Hospital\/Institute of Mental Health Peking University Beijing China"},{"name":"National Clinical Research Center for Mental Disorders &amp; The Key Laboratory of Mental Health Ministry of Health (Peking University) Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"An","sequence":"additional","affiliation":[{"name":"Sixth Hospital\/Institute of Mental Health Peking University Beijing China"},{"name":"National Clinical Research Center for Mental Disorders &amp; 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