{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:56:59Z","timestamp":1791986219680,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:00:00Z","timestamp":1622592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the correlation between acetylcholine receptor antibodies (AChR\u2010Ab) concentration levels and individualized clinical symptoms in patients with AChR myasthenia gravis (AChR\u2010MG) in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ELISA was used to determine the concentration of AChR\u2010Ab in patients with MG. The Myasthenia Gravis Foundation of America (MGFA) Clinical Classification, Quantitative Myasthenia Gravis (QMG) score, and MG\u2010specific activities of daily living (MG\u2010ADL) scoring systems were used to evaluate the clinical status of patients. Spearman correlation analysis was used to determine the correlation between the AChR\u2010Ab concentration and clinical score. The changes in the antibody concentration and clinical score are shown in MGFA\u2010antibody concentration\u2013treatment plots.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Autoantibody detection tests were performed in 67 patients, and their clinical scores were recorded. Forty\u2010nine patients received immunosuppressive therapy, 17 patients received pyridostigmine only, and 1 patient under thymectomy without any medication. The AChR\u2010Ab concentration correlated with the MGFA Classification in 5 (29.4%) patients in the pyridostigmine\u2010only group and 15 (30.6%) patients in the immunosuppressive drug group. The changes in the MGFA Classification preceded the changes in the AChR\u2010Ab concentration in 4 (23.5%) patients treated with pyridostigmine and 10 (20.4%) patients on immunosuppressive drugs. In patients on oral non\u2010steroidal immunosuppressants, the AChR\u2010Ab concentration changed by more than 50%, whereas the MGFA Classification did not increase. The AChR\u2010Ab concentration decreased in 17\/32 (53.1%) patients after thymectomy, and then increased, whereas the AChR\u2010Ab concentration increased in 15\/32 (46.9%) patients and the MGFA Classification decreased in 27\/32 (81.8%) patients after thymectomy. The AChR\u2010Ab concentration presented a slight correlation with the corresponding MGFA, QMG, and MG\u2010ADL in patients with thymoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>In the Chinese AChR\u2010MG population, the Changes in the AChR\u2010Ab concentration in individuals with AChR\u2010MG did not consistently correlate with the severity of clinical symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2203","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T08:48:53Z","timestamp":1622623733000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["No correlation between acetylcholine receptor antibody concentration and individual clinical symptoms of myasthenia gravis: A systematic retrospective study involving 67 patients"],"prefix":"10.1002","volume":"11","author":[{"given":"Lulu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Zhengzhou University Zhengzhou China"},{"name":"Department of Neuroimmunology, Henan Institute of Medical and Pharmaceutical Sciences Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neuroimmunology, Henan Institute of Medical and Pharmaceutical Sciences Zhengzhou University Zhengzhou China"},{"name":"Basic Medical College Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haonan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neuroimmunology, Henan Institute of Medical and Pharmaceutical Sciences Zhengzhou University Zhengzhou China"},{"name":"BGI College Zhengzhou University 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