{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:48:42Z","timestamp":1778125722736,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["U01MH101719"],"award-info":[{"award-number":["U01MH101719"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["U01MH119738"],"award-info":[{"award-number":["U01MH119738"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH119738"],"award-info":[{"award-number":["MH119738"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["U01MH101722"],"award-info":[{"award-number":["U01MH101722"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH117014"],"award-info":[{"award-number":["R01MH117014"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Intelligence quotient (IQ) testing is standard for evaluating cognitive abilities in genomic studies but requires professional expertise in administration and interpretation, and IQ scores do not translate into insights on implicated brain systems that can link genes to behavior. Individuals with 22q11.2 deletion syndrome (22q11.2DS) often undergo IQ testing to address special needs, but access to testing in resource\u2010limited settings is challenging. The brief Penn Computerized Neurocognitive Battery (CNB) provides measures of cognitive abilities related to brain systems and can screen for cognitive dysfunction. To examine the relation between CNB measures and IQ, we evaluated participants with the 22q11.2DS from Philadelphia and Tel Aviv (\n                    <jats:italic>N\u00a0<\/jats:italic>\n                    =\u00a0117; 52 females; mean age 18.8) who performed both an IQ test and the CNB with a maximum of 5 years between administrations and a subsample (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a024) who had both IQ and CNB assessments at two time points. We estimated domain\u2010level CNB scores using exploratory factor analysis (including bifactor for overall scores) and related those scores (intraclass correlations (ICCs)) to the IQ scores. We found that the overall CNB accuracy score showed similar correlations between time 1 and time 2 as IQ (0.775 for IQ and 0.721 for CNB accuracy), correlated well with the IQ scores (ICC\u00a0=\u00a00.565 and 0.593 for time 1 and time 2, respectively), and correlated similarly with adaptive functioning (0.165 and 0.172 for IQ and CNB, respectively). We provide a crosswalk (from linear equating) between standardized CNB and IQ scores. Results suggest that one can substitute the CNB for IQ testing in future genetic studies that aim to probe specific domains of brain\u2010behavior relations beyond IQ.\n                  <\/jats:p>","DOI":"10.1002\/brb3.2221","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T06:47:36Z","timestamp":1625208456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Relationship between intelligence quotient measures and computerized neurocognitive performance in 22q11.2 deletion syndrome"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9657-1996","authenticated-orcid":false,"given":"Ruben C.","family":"Gur","sequence":"first","affiliation":[{"name":"Department of Psychiatry Brain Behavior Laboratory Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Lifespan Brain Institute (LiBI), Children's Hospital of Philadelphia and Penn Medicine  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler M.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Brain Behavior Laboratory Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Lifespan Brain Institute (LiBI), Children's Hospital of Philadelphia and Penn Medicine  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronnie","family":"Weinberger","sequence":"additional","affiliation":[{"name":"The Behavioral Neurogenetics Center Edmond and Lily Safra Children\u2019s Hospital Child Psychiatry Division Sheba Medical Center Tel Hashomer  Ramat Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehud","family":"Mekori\u2010Domachevsky","sequence":"additional","affiliation":[{"name":"The Behavioral Neurogenetics Center Edmond and Lily Safra Children\u2019s Hospital Child Psychiatry Division Sheba Medical Center Tel Hashomer  Ramat Gan Israel"},{"name":"Department of Psychiatry Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raz","family":"Gross","sequence":"additional","affiliation":[{"name":"The Behavioral Neurogenetics Center Edmond and Lily Safra Children\u2019s Hospital Child Psychiatry Division Sheba Medical Center Tel Hashomer  Ramat Gan Israel"},{"name":"Department of Psychiatry Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beverly S.","family":"Emanuel","sequence":"additional","affiliation":[{"name":"Division of Human Genetics and 22q and You Center Children's Hospital of Philadelphia Department of Pediatrics Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine H.","family":"Zackai","sequence":"additional","affiliation":[{"name":"Division of Human Genetics and 22q and You Center Children's Hospital of Philadelphia Department of Pediatrics Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Moss","sequence":"additional","affiliation":[{"name":"Division of Human Genetics and 22q and You Center Children's Hospital of Philadelphia Department of Pediatrics Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert Sean","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Brain Behavior Laboratory Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Lifespan Brain Institute (LiBI), Children's Hospital of Philadelphia and Penn Medicine  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel E.","family":"McGinn","sequence":"additional","affiliation":[{"name":"Division of Human Genetics and 22q and You Center Children's Hospital of Philadelphia Department of Pediatrics Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3272-5458","authenticated-orcid":false,"given":"Terrence Blaine","family":"Crowley","sequence":"additional","affiliation":[{"name":"Division of Human Genetics and 22q and You Center Children's Hospital of Philadelphia Department of Pediatrics Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"McDonald\u2010McGinn","sequence":"additional","affiliation":[{"name":"Division of Human Genetics and 22q and You Center Children's Hospital of Philadelphia Department of Pediatrics Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doron","family":"Gothelf","sequence":"additional","affiliation":[{"name":"The Behavioral Neurogenetics Center Edmond and Lily Safra Children\u2019s Hospital Child Psychiatry Division Sheba Medical Center Tel Hashomer  Ramat Gan Israel"},{"name":"Department of Psychiatry Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel E.","family":"Gur","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Brain 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