{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T03:05:00Z","timestamp":1788145500807,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>Polyneuropathy is a common neurological disorder with many potential causes. An essential part in screening, diagnosis, and follow\u2010up evaluation of polyneuropathy is testing of the sensory function including vibratory sensation. The graduated Rydel\u2010Seiffer tuning fork and the biothesiometer have been developed to quantify vibratory sensation through detection thresholds. The aim of this study is to compare the vibration detection thresholds determined by the two instruments regarding intraindividual temporal changes, interindividual variation in healthy subjects and comparison of the diagnostic value in patients with a clinical suspicion of polyneuropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ninety\u2010four healthy subjects, 98 patients with and 97 patients without a diagnosis of polyneuropathy were included. Quantitative sensory testing including biothesiometry, structured clinical examination, and nerve conduction studies were performed three times during 52\u00a0weeks in healthy subjects and once in patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were no significant changes over time for neither the Rydel\u2010Seiffer tuning fork nor the biothesiometer, and both had larger between\u2010subject variation than within\u2010subject variation. Relative intertrial variability was largest for the biothesiometer. Diagnostic value (sensitivity, specificity, positive predictive value, and negative predictive value) was moderate for both methods (Rydel\u2010Seiffer tuning fork: 58%, 74%, 70%, 64%; biothesiometer: 47%, 77%, 68%, 59%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>The Rydel\u2010Seiffer tuning fork and the biothesiometer have a low test\u2010retest and time dependent variation. They perform almost equally as diagnostic tools in patients with suspected polyneuropathy with a tendency toward better performance of the tuning fork.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2230","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T18:14:30Z","timestamp":1622830470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Test\u2010retest and time dependent variation and diagnostic values of vibratory sensation determined by biothesiometer and the Rydel\u2010Seiffer tuning fork"],"prefix":"10.1002","volume":"11","author":[{"given":"Bolette","family":"Wittenberg","sequence":"first","affiliation":[{"name":"Research Unit for Neurology Odense University Hospital University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toke 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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troels S.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Danish Pain Research Center Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Neurology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gaist","sequence":"additional","affiliation":[{"name":"Research Unit for Neurology Odense University Hospital University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren H.","family":"Sindrup","sequence":"additional","affiliation":[{"name":"Research Unit for Neurology Odense University Hospital University of Southern Denmark  Odense 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