{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:02:38Z","timestamp":1791241358441,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Temporal lobe epilepsy secondary to hippocampal sclerosis is related to epileptogenic networks rather than a focal epileptogenic source. Graph\u2010theoretical gray and white matter networks may help to identify alterations within these epileptogenic networks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010seven patients with hippocampal sclerosis and 14 controls underwent magnetic resonance imaging, including 3D\u2010T1, fluid\u2010attenuated inversion recovery, and diffusion tensor imaging. Subject\u2010specific structural gray and white matter network properties (normalized path length, clustering, and small\u2010worldness) were reconstructed. Group differences and differences between those with higher and lower seizure burden (&lt;4 vs.\u00a0\u22654 average monthly seizures in the last year) in network parameters were evaluated. Additionally, correlations between network properties and disease\u2010related variables were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All patients with hippocampal sclerosis as one group did not have altered gray or white matter network properties (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a0.05). Patients with lower seizure burden had significantly lower gray matter small\u2010worldness and normalized clustering compared to controls and those with higher seizure burden (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.04). A higher number of monthly seizures was significantly associated with increased gray and white matter small\u2010worldness, indicating a more rigid network.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall, there were no differences in network properties in this group of patients with hippocampal sclerosis. However, patients with lower seizure burden had significantly lower gray matter network indices, indicating a more random organization. The correlation between higher monthly seizures and a more rigid network is driven by those with higher seizure burden, who presented a more rigid network compared to those with a lower seizure burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2237","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T10:08:14Z","timestamp":1623233294000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of seizure burden on structural global brain networks in patients with unilateral hippocampal sclerosis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4902-0021","authenticated-orcid":false,"given":"Diogo Goulart","family":"Corr\u00eaa","sequence":"first","affiliation":[{"name":"Cl\u00ednica de Diagn\u00f3stico por Imagem (CDPI)\/DASA  Avenida das Am\u00e9ricas, Barra da Tijuca Rio de Janeiro Brazil"},{"name":"Instituto Estadual do C\u00e9rebro Paulo Niemeyer  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty M.","family":"Tijms","sequence":"additional","affiliation":[{"name":"Department of Neurology Alzheimer Center, Amsterdam University Medical Centers, Vrije Universiteit  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Dicks","sequence":"additional","affiliation":[{"name":"Department of Neurology Alzheimer Center, Amsterdam University Medical Centers, Vrije Universiteit  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia","family":"R\u00eago","sequence":"additional","affiliation":[{"name":"Department of Neurology Epilepsy Center Hospital Universit\u00e1rio Clementino Fraga Filho, Federal University of Rio de Janeiro  Cidade Universit\u00e1ria, Ilha do Fund\u00e3o Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soniza Vieira","family":"Alves\u2010Leon","sequence":"additional","affiliation":[{"name":"Department of Neurology Epilepsy Center Hospital Universit\u00e1rio Clementino Fraga Filho, Federal University of Rio de Janeiro  Cidade Universit\u00e1ria, Ilha do Fund\u00e3o Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Marcondes","sequence":"additional","affiliation":[{"name":"Department of Neurology Epilepsy Center Hospital Universit\u00e1rio Clementino Fraga Filho, Federal University of Rio de Janeiro  Cidade Universit\u00e1ria, Ilha do Fund\u00e3o Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerson Leandro","family":"Gasparetto","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de Diagn\u00f3stico por Imagem (CDPI)\/DASA  Avenida das Am\u00e9ricas, Barra da Tijuca Rio de Janeiro Brazil"},{"name":"Instituto Estadual do C\u00e9rebro Paulo Niemeyer  Rio de Janeiro 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