{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:04:31Z","timestamp":1772118271585,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["1808085MH263"],"award-info":[{"award-number":["1808085MH263"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005269","name":"Provincial Foundation for Excellent Young Talents of Colleges and Universities of Anhui Province","doi-asserted-by":"publisher","award":["gxyqZD2019036"],"award-info":[{"award-number":["gxyqZD2019036"]}],"id":[{"id":"10.13039\/501100005269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Degeneration changes of the basal forebrain (BF) are suggested to play an important role in cognitive impairment and memory loss in patients with Alzheimer's disease and Parkinson's disease. However, little is known about if and how the structure and function of BF are abnormal in Wilson's disease (WD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here, we employed the structural and resting\u2010state functional magnetic resonance imaging (fMRI) data from 19 WD individuals and 24 healthy controls (HC). Voxel\u2010based morphometry (VBM) and functional connectivity analysis were applied to investigate the structural and functional degeneration changes of BF in WD. Moreover, the linear regression analyses were performed in the patient group to depict the correlations between the aberrant gray volume and functional connectivity of the BF and clinical performances, such as the prospective memory (PM) and mini\u2010mental state examination (MMSE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>VBM analysis showed that compared with HC, the volume of overlapping cell groups of BF termed CH1\u20133 and CH4 was significantly reduced in WD. Additionally, the decreased functional connectivity of the CH4 was distributed in the bilateral temporal\u2010parietal junction (TPJ), right thalamus, orbitofrontal gyrus (ORB), and left middle cingulate cortex (MCC). The performances of the time\u2010based prospective memory (TBPM) and event\u2010based prospective memory (EBPM) were related to reduced functional connectivity between CH4 and right ORB. Besides, the functional connectivity of left TPJ was also significantly correlated with EBPM in WD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings indicated that the degenerative changes of BF may affect PM through the innervation brain function and may help to understand the neural mechanisms underlying cognitive impairment in WD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2239","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T06:29:37Z","timestamp":1623652177000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The degeneration changes of basal forebrain are associated with prospective memory impairment in patients with Wilson's disease"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0787-6852","authenticated-orcid":false,"given":"Yutong","family":"Wu","sequence":"first","affiliation":[{"name":"School of Medical Information Engineering Anhui University of Chinese Medicine  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Medical Information Engineering Anhui University of Chinese Medicine  Hefei Anhui China"},{"name":"Centers for Biomedical Engineering University of Science and Technology of China  Hefei Anhui 230027 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medical Information Engineering Anhui University of Chinese Medicine  Hefei Anhui 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