{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:41:25Z","timestamp":1773009685318,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Erenumab is a monoclonal antibody acting against calcitonin gene\u2010related peptide receptor and approved for the preventive treatment of chronic migraine. The aim of the present study is to identify clinical predictors of good response in patients with chronic migraine and medication overuse\u2010headache.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>This was a retrospective single\u2010center not funded study. Enrolled patients were affected by chronic migraine and medication overuse\u2010headache treated with erenumab monthly, up to 1 year. At 1 year, patients were classified as good responders if they displayed a \u226550% reduction in the number of headache days per months compared to the baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After 1 year, a significant improvement in the number of headache days per months, analgesic consumption, 6\u2010items headache impact test, and migraine disability assessment questionnaire scores were obtained compared to the baseline. Patients who obtained a \u226550% reduction in the number of headache days per month compared to the baseline displayed a longer history of medication overuse\u2010headache, a higher number of painkillers taken per month at the baseline and a higher number of failed preventive treatments in the past.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with longer medication overuse\u2010headache duration, higher analgesic intake, and a higher number of previous preventive treatment failures may receive less benefit with erenumab.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2260","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T03:45:43Z","timestamp":1626407143000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Predictors of response to erenumab after 12 months of treatment"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8432-1888","authenticated-orcid":false,"given":"Carlo","family":"Baraldi","sequence":"first","affiliation":[{"name":"PhD School in Neuroscience Department of Biomedical Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia Lo","family":"Castro","sequence":"additional","affiliation":[{"name":"Post\u2010graduate School of Pharmacology and Clinical Toxicology Department of Biomedical Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Michela","family":"Cainazzo","sequence":"additional","affiliation":[{"name":"Medical Toxicology\u2010headache and Drug Abuse Research Center Department of Biomedical Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Pani","sequence":"additional","affiliation":[{"name":"Medical Toxicology\u2010headache and Drug Abuse Research Center Department of Biomedical Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"},{"name":"Pharmacology Unit Department of Biomedical Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"},{"name":"Department of Psychiatry and Behavioral Sciences University of Miami  Miami Florida USA"},{"name":"VeraSci  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Guerzoni","sequence":"additional","affiliation":[{"name":"Medical Toxicology\u2010headache and Drug Abuse Research Center Department of Biomedical Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena 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