{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:28:05Z","timestamp":1791228485014,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lower urinary tract symptoms (LUTS), such as voiding symptoms, overactive bladder, and interstitial cystitis, and anxiety disorders are often comorbid conditions in patients. However, the existing evidence regarding the rates and nature of the co\u2010occurrence of these conditions has not been systematically evaluated. The aim of this study was to examine these relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a systematic review and meta\u2010analysis to examine the relationship between LUTS and anxiety. We searched for articles published from January 1990 to July 2019 in PubMed, CENTRAL, PsycINFO, and Google Scholar. Outcomes were anxiety\u2010related disorders and symptoms (clinically significant anxiety) and LUTS. We performed random\u2010effects meta\u2010analyses, inspected funnel plots, and applied the Egger's test to evaluate publication bias. We followed PRISMA guidelines and recorded our protocol on PROSPERO (ID\u00a0=\u00a0CRD42019118607).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 814 articles, of which 94 fulfilled inclusion criteria, and 23 had sufficient data for meta\u2010analysis. The odds ratio (OR) for clinically significant anxiety among individuals with LUTS was 2.87 (95% CI: 2.38,3.46,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). The OR for LUTS among individuals with clinically significant anxiety was 2.87 (95% CI: 1.07,7.74,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), although very few studies examined this relationship. A large value of I\n                      <jats:sup>2<\/jats:sup>\n                      index suggests high heterogeneity between studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results demonstrate a significant association between clinically significant anxiety and LUTS in both females and males. There were limited studies on younger individuals and on individuals ascertained for clinically significant anxiety, which should motivate further study in these areas. Understanding the co\u2010occurrence of these conditions will lead to better prevention and interventions to ameliorate the progression of the symptoms and improve the quality of life. A thorough assessment of anxiety may provide more optimal care for LUTS patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2268","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T04:52:25Z","timestamp":1629175945000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Systematic review and meta\u2010analysis identify significant relationships between clinical anxiety and lower urinary tract symptoms"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6087-9537","authenticated-orcid":false,"given":"Behrang","family":"Mahjani","sequence":"first","affiliation":[{"name":"Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York USA"},{"name":"Seaver Autism Center for Research and Treatment Icahn School of Medicine at Mount Sinai  New York USA"},{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"},{"name":"Division of Tics, OCD, and Related Disorders Icahn School of Medicine at Mount Sinai  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotta Renstr\u00f6m","family":"Koskela","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Pelvic Cancer Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Batuure","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York USA"},{"name":"Division of Tics, OCD, and Related Disorders Icahn School of Medicine at Mount Sinai  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Gustavsson Mahjani","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York USA"},{"name":"Seaver Autism Center for Research and Treatment Icahn School of Medicine at Mount Sinai  New York USA"},{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Janecka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York USA"},{"name":"Seaver Autism Center for Research and Treatment Icahn School of Medicine at Mount Sinai  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"Hultman","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Reichenberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York USA"},{"name":"Seaver Autism Center for Research and Treatment Icahn School of Medicine at Mount Sinai  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Buxbaum","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York USA"},{"name":"Seaver Autism Center for Research and Treatment Icahn School of Medicine at Mount Sinai  New York USA"},{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai  New York USA"},{"name":"Department of Neuroscience Icahn School of Medicine at Mount Sinai  New York USA"},{"name":"The Mindich Child Health and Development Institute Icahn School of Medicine at Mount Sinai  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olof","family":"Akre","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Pelvic Cancer Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy E.","family":"Grice","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York USA"},{"name":"The Mindich Child Health and Development Institute Icahn School of Medicine at Mount Sinai  New York USA"},{"name":"Division of Tics, OCD, and Related Disorders Icahn School of Medicine at Mount Sinai  New York USA"},{"name":"Friedman Brain Institute Icahn School of Medicine at Mount Sinai  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4082\/kjfm.2016.37.1.25"},{"key":"e_1_2_8_3_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders, 4th ed. 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