{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T18:23:31Z","timestamp":1773858211075,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T00:00:00Z","timestamp":1396915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nonmotor symptoms are probably present prior to, early on, and following, a diagnosis of Parkinson's disease. Nonmotor symptoms may hold important information about the progression of Parkinson's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluated the total early and prediagnostic morbidities in the 3\u00a0years before a hospital contact leading to a diagnosis of Parkinson's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective morbidity data from Danish National Patient Registry records (1997\u20132007) of 10,490 adult patients with a secondary care diagnosis of Parkinson's disease were compared with 42,505 control cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Parkinson's disease was associated with significantly higher morbidity rates associated with conditions in the following categories: mental and psychiatric, nervous system, gastrointestinal, musculoskeletal system and connective tissue, genitourinary, abnormal clinical and laboratory findings, injury, poisoning and certain other external causes, and other factors influencing health status and contact with health services. It was negatively associated with neoplasm, cardiovascular, and respiratory diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with a diagnosis of Parkinson's disease present significant differences in morbidities early on, following, and prior to, their diagnosis, compared with healthy controls.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.228","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T06:13:02Z","timestamp":1396937582000},"page":"446-452","source":"Crossref","is-referenced-by-count":17,"title":["Morbidity in early Parkinson's disease and prior to diagnosis"],"prefix":"10.1002","volume":"4","author":[{"given":"Rune","family":"Frandsen","sequence":"first","affiliation":[{"name":"Department of Clinical Neurophysiology Danish Center for Sleep Medicine Glostrup Hospital Glostrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Kjellberg","sequence":"additional","affiliation":[{"name":"Danish Institute for Health Services Research Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikke","family":"Ibsen","sequence":"additional","affiliation":[{"name":"itracks Klosterport 4E Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poul","family":"Jennum","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology Danish Center for Sleep Medicine Glostrup Hospital Glostrup Denmark"},{"name":"Faculty of Health Sciences Center for Healthy Aging University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.08.034"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2009.00369.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9497-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2008.11.010"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-002-0808-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00065-9"},{"key":"e_1_2_7_8_1","first-page":"901","article-title":"Role of coronary artery spasm in ischemic heart disease. 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