{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:39:25Z","timestamp":1785332365757,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Neuromyelitis optica spectrum disorder (NMOSD; also known as Devic syndrome) is a clinical syndrome of central nervous system characterized by immune mediated attacks of acute optic neuritis and myelitis. Paraneoplastic neurological syndrome is a group of nervous system disorders resulting from the remote immune effects of malignant neoplasm. NMOSD occurs mostly in young people, and tumor is not a common cause, especially recurrent tumor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reported a case of a 59\u2010year\u2010old man who developed anti\u2010aquaporin\u20104 IgG positive longitudinally extensive myelitis. We also summarized and analyzed previously reported cases of paraneoplastic NMOSD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among these 43 patients, 88.4% patients are female. The largest number of patients is between 60 and 69 years old. Breast cancer and lung cancer are the most common types. The most common lesions were located in the cervicothoracic region with patchy gadolinium enhancement. The existing treatment can only delay rather than stop the progress of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It is necessary to perform tumor screening in patients with NMOSD, especially patients over 50 years.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.2282","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T20:52:35Z","timestamp":1631652755000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["AQP4\u2010IgG positive paraneoplastic NMOSD: A case report and review"],"prefix":"10.1002","volume":"11","author":[{"given":"Manqiu","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Neurology The First Hospital of Jilin University Changchun Jilin Province P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Hospital of Jilin University Changchun Jilin Province P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4338-9514","authenticated-orcid":false,"given":"Li","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Hospital of Jilin University Changchun Jilin Province P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2014.06.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2017.10.030"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1179\/2045772312Y.0000000018"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2018.14.2.246"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2017.12.012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.03.031"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2019.1648210"},{"issue":"7","key":"e_1_2_9_9_1","first-page":"660","article-title":"Paraneoplastic neuromyelitis optica spectrum disorders: Three new cases and a review of the literature","volume":"126","author":"Cai G.","year":"2016","journal-title":"International Journal of Neuroscience"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-009-0112-0"},{"key":"e_1_2_9_11_1","first-page":"1033","article-title":"Myelite subaigu\u00eb compliqu\u00e9e de n\u00e9vrite optique","volume":"8","author":"Devic E.","year":"1894","journal-title":"Le Bulletin M\u00e9dicale"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000169754.38944.a4"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2018.10.118"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.04.031"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.6331"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2013.07.003"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-018-0721-y"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000222"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-10235-5"},{"issue":"22","key":"e_1_2_9_20_1","article-title":"Paraneoplastic neurological syndromes","volume":"2","author":"Honnorat J.","year":"2007","journal-title":"Orphanet Journal of Rare Diseases"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182343377"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-7-52"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0214-9"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014229"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-015-0387-9"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.5636"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2017.05.009"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17551-X"},{"issue":"3","key":"e_1_2_9_29_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.14712\/fb2016062030131","article-title":"Down\u2010regulation of AQP4 inhibits proliferation, migration and invasion of human breast cancer cells","volume":"62","author":"Li Y. 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