{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:00:25Z","timestamp":1772118025862,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Presence of sleep\u2010disordered breathing (SDB) and especially obstructive sleep apnea (OSA) is a known risk factor for ischemic stroke. Additionally, SDB effects negatively on recovery after stroke. Up to one fourth of strokes are present on awakening. The link between OSA and wake\u2010up stroke (WUS) has been suggested. We aim to determine the association between OSA and WUS in a Finnish stroke unit cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>An observational prospective longitudinal study consisted of 95 TIA (transient ischemic attack) and mild to moderate stroke patients referred to a Stroke Unit in Finland. Respiratory polygraphy was performed within 72\u00a0h of hospital admission. Patients were classified into WUS and non\u2010WUS, and functional outcome measures (mRS, rehabilitation, hospitalization time) were collected. Functional outcomes and prevalence of OSA were compared between non\u2010WUS and WUS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      OSA (AHI\u00a0\n                      <jats:styled-content>&gt;<\/jats:styled-content>\n                      \u00a015\/h) was more frequent among WUS than non\u2010WUS (71% and 36%, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.009). Functional outcome measured with mRS was worse in patients with WUS than non\u2010WUS on registration day and at hospital discharge (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001). Need for rehabilitation in WUS was 43% of cases compared to 23% of non\u2010WUS (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.067). Hospitalization time was longer (5\u201315days) in 55% of WUS and 41% of non\u2010WUS patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.261).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Moderate\u2010to\u2010severe OSA is related to WUS compared to non\u2010WUS. In addition, WUS have worse short\u2010term outcomes measured in mRS. Further studies are needed to determine if OSA is causally linked to WUS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2284","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T23:46:03Z","timestamp":1626911163000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Wake\u2010up strokes are linked to obstructive sleep apnea and worse early functional outcome"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3807-9941","authenticated-orcid":false,"given":"Tuuli\u2010Maria","family":"Haula","sequence":"first","affiliation":[{"name":"Unit of Neurology Satakunta Hospital District Clinical Neurosciences University of Turku  Pori Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha","family":"Puustinen","sequence":"additional","affiliation":[{"name":"Unit of Neurology Satakunta Hospital District Social Security Centre of Pori City of Pori Clinical Pharmacy Group University of Helsinki  Pori Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Takala","sequence":"additional","affiliation":[{"name":"Unit of Clinical Neurophysiology Satakunta Hospital District  Pori Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anu","family":"Holm","sequence":"additional","affiliation":[{"name":"Unit of Clinical Neurophysiology Satakunta Hospital District Faculty of Health and Welfare Satakunta University of Applied Sciences  Pori Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(88)90669-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00398-1"},{"key":"e_1_2_11_5_1","article-title":"Chapter 62","volume":"22","author":"Bassetti C. 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