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However, topiramate is still viewed as an off\u2010label medication for migraine treatment in China, partly because of the limited evidence in Chinese patients. We summarize the effects of topiramate on the frequency, severity, quality\u2010of\u2010life, and adverse event among migraine patients, including children and adolescent in this review, so as to provide reference for Chinese doctors.<\/jats:p>","DOI":"10.1002\/brb3.2290","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T08:29:37Z","timestamp":1630571377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Advances in topiramate as prophylactic treatment for migraine"],"prefix":"10.1002","volume":"11","author":[{"given":"Chuan","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1530-7377","authenticated-orcid":false,"given":"Ge","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104637.2007.00389.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.8.965"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101157.2000.tb06048.x"},{"issue":"8","key":"e_1_2_9_6_1","first-page":"943","article-title":"Topiramate in migraine prophylaxis\u2013results from a placebo\u2010controlled trial with propranolol as an active control","volume":"251","author":"Diener H. 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