{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T07:31:17Z","timestamp":1767771077016,"version":"build-2238731810"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to investigate the efficacy of modified Ginseng Yangrong decoction (GSYRD) promoting angiogenesis after ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In an in vivo study, rats that survived surgery were allocated into four groups: the control group and model group were treated with normal saline, the GSYRD group was treated with 18.9\u00a0mg\/kg of GSYRD daily, and the positive control group was treated with Tongxinluo (TXL) (1\u00a0g\/kg\/d). At the end of the seven\u2010day treatment, the area of cerebral infarction, the expression changes of miRNA\u2010210 and ephrin A3 were determined. In an in vitro study, HUVECs were divided into a normal control serum group (NC group), normal control serum OGD group (Oxygen Glucose Deprivation group) (OGD group), OGD + drug\u2010containing serum group (OGD+GSYRD group), and OGD + drug\u2010containing serum + ES group (Endostatin group) (OGD+GSYRD+ES group). The cells in all groups except the NC group were cultured in a sugar\u2010free DMEM medium under hypoxia for 48\u00a0h. Cell proliferation, angiogenic structure formation ability, the expression changes of miRNA\u2010210, ephrin A3, and the HIF\/VEGF\/Notch signaling pathway\u2010related molecules were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In vivo, GSYRD significantly reduced infarct size (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01), the expression of miRNA\u2010210 and ephrin A3 were decreased in the GSYRD group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). In vitro, the cell proliferation and tube formation ability were significantly increased in the GSYRD group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05), and the expression of miRNA\u2010210 and ephrin A3 was decreased (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). In addition, in the GSYRD group, the expression of the HIF\/VEGF\/Notch signaling pathway\u2010related molecules was significantly increased (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01 or\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GSYRD promotes cerebral protection following angiogenesis and ischemic brain injury. The specific mechanism was activating the HIF\/VEGF\/Notch signaling pathway via miRNA\u2010210.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2295","type":"journal-article","created":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T14:01:56Z","timestamp":1627826516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Modified Renshen Yangrong decoction enhances angiogenesis in ischemic stroke through promotion of MicroRNA\u2010210 expression by regulating the HIF\/VEGF\/Notch signaling pathway"],"prefix":"10.1002","volume":"11","author":[{"given":"Ce","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Hebei TCM Formula Granule Innovation Center Hebei University of Chinese Medicine  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Health Commission of 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