{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:52:50Z","timestamp":1791337970156,"version":"4.3.1"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T00:00:00Z","timestamp":1629590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>The management of post\u2010stroke epilepsy (PSE) should ideally include prevention of both seizure and adverse effects; however, an optimal antiseizure medications (ASM) regimen has yet been established. The purpose of this study is to assess seizure recurrence, retention, and tolerability of older\u2010generation and newer\u2010generation ASM for PSE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective multicenter cohort study (PROgnosis of Post\u2010Stroke Epilepsy [PROPOSE] study) was conducted from November 2014 to September 2019 at eight hospitals. A total of 372 patients admitted and treated with ASM at discharge were recruited. Due to the non\u2010interventional nature of the study, ASM regimen was not adjusted and followed standard hospital practices. The primary outcome was seizure recurrence in patients receiving older\u2010generation and newer\u2010generation ASM. The secondary outcomes were the retention and tolerability of ASM regimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 372 PSE patients with ASM at discharge (median [IQR] age, 73 [64\u201381] years; 139 women [37.4%]), 36 were treated with older\u2010generation, 286 with newer\u2010generation, and 50 with mixed\u2010generation ASM. In older\u2010 and newer\u2010generation ASM groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0322), 98 patients (30.4%) had recurrent seizures and 91 patients (28.3%) switched ASM regimen during the follow\u2010up (371 [347\u2013420] days). Seizure recurrence was lower in newer\u2010generation, compared with the older\u2010generation, ASM (hazard ratio [HR], 0.42, 95%CI 0.27\u20130.70;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0013). ASM regimen withdrawal and change of dosages were lower in newer\u2010generation ASM (HR, 0.34, 95% CI 0.21\u20130.56,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Newer\u2010generation ASM possess advantages over older\u2010generation ASM for secondary prophylaxis of post\u2010stroke seizures in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2330","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T01:48:38Z","timestamp":1629683318000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Antiseizure medications for post\u2010stroke epilepsy: A real\u2010world prospective cohort study"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6023-236X","authenticated-orcid":false,"given":"Tomotaka","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Neurology National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Fukuma","sequence":"additional","affiliation":[{"name":"Department of Neurology National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Neurology National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Motoyama","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Mizobuchi","sequence":"additional","affiliation":[{"name":"Department of Neurology Nakamura Memorial Hospital  Sapporo Japan"},{"name":"Clinic of Minami\u2010ichijyo Neurology  Sappro Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Neurology Kobe City Medical Center General Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Matsuki","sequence":"additional","affiliation":[{"name":"Department of Neurology St. Mary's Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Manabe","sequence":"additional","affiliation":[{"name":"Department of Neurology National Hospital Organization Okayama Medical Center  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichiro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Neurology Toyota Memorial Hospital  Toyota Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Neurology National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naruhiko","family":"Kamogawa","sequence":"additional","affiliation":[{"name":"Department of Neurology National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Ishiyama","sequence":"additional","affiliation":[{"name":"Department of Neurology National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Neurology Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Shimotake","sequence":"additional","affiliation":[{"name":"Department of Neurology Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Departments of Preventive Medicine and Epidemiology National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Onozuka","sequence":"additional","affiliation":[{"name":"Departments of Preventive Medicine and Epidemiology National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Medicine National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Medicine National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Murayama","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riki","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Division of Neurology Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neurology Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Epilepsy, Movement Disorders and Physiology Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7102-4048","authenticated-orcid":false,"given":"Masafumi","family":"Ihara","sequence":"additional","affiliation":[{"name":"Department of Neurology National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the PROPOSE Study Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8586-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2018.08.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2008.9690"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2014.02.007"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15946-1"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342669"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13448"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13813"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12550"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13670"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20902742"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/11631540-000000000-00000"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e3180333069"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12074"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01945.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e3182784729"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/2396987317705536"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2011.05.003"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12766"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-011-1051-2"},{"issue":"1","key":"e_1_2_11_22_1","first-page":"212","article-title":"Clinical predictors of seizure recurrence after the first post\u2010ischemic stroke seizure","volume":"16","author":"Kim H. J.","year":"2016","journal-title":"BMC Neurology [Electronic Resource]"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejro.2018.10.004"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2018.11.013"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11040418"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16366"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13025"},{"issue":"37","key":"e_1_2_11_28_1","first-page":"iii","article-title":"A randomised controlled trial examining the longer\u2010term outcomes of standard versus new antiepileptic drugs. The SANAD trial","volume":"11","author":"Marson A. G.","year":"2007","journal-title":"Health Technology Assessment (Winchester, England)"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14554"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.0278"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.oa.2019-0225"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-016-0663-7"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000313157.15089.e6"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.67.12_suppl_4.S3"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)33064-8"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.11.018"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2017.02.002"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136200"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2017.09.007"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12926"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000098"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2018-000175"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285616654423"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.2330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.2330","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.2330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T03:52:22Z","timestamp":1693194742000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.2330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,22]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/brb3.2330"],"URL":"https:\/\/doi.org\/10.1002\/brb3.2330","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.2330\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2330\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2330\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2330\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2330\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,22]]},"assertion":[{"value":"2021-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2330"}}