{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:59:15Z","timestamp":1772117955162,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate any seasonality in the incidence of anti\u2010GQ1b antibody syndrome (AGS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective observational study in all hospitalized patients in local public hospitals from January 2013 to December 2018. AGS was defined by hospitalized patients with positive serum anti\u2010GQ1b IgG, presumably encompassing Miller\u2010Fisher syndrome, Bickerstaff brainstem encephalitis and Guillain\u2013Barr\u00e9 syndrome (GBS) variants. GBS cases were retrieved from the computerized database by diagnostic label.\n                      <jats:italic>Campylobacter jejuni<\/jats:italic>\n                      infection (CJI) injection was identified by positive stool culture. Monthly incidence rates of AGS, GBS and CJI were calculated. Poisson and negative binomial regression models with long\u2010term time trend were fitted to characterize the seasonal pattern.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 237, 572 and 2434 cases of AGS, GBS and CJI were identified, respectively, in a population of 7.3 million. The annual incidence rate of AGS was 0.54 per 100,000 person\u2010years. AGS was demonstrated to have an annual peak in the spring season, from March to April, which was congruent with that of GBS and slightly lagged the annual peak of CJI from February to March (likelihood ratio tests all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001 for the seasonal terms).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The incidence of AGS peaks in springtime, which is congruent with that of GBS and lags around one month after that of CJI. We demonstrated that AGS has a clear seasonality in occurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2337","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T15:24:31Z","timestamp":1630941871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Seasonality in the incidence of anti\u2010GQ1b antibody syndrome\u2014A territory\u2010wide study"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9346-3877","authenticated-orcid":false,"given":"Richard Shek\u2010kwan","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Medicine, Queen Mary Hospital University of Hong Kong  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric H. Y.","family":"Lau","sequence":"additional","affiliation":[{"name":"School of Public Health, Li Ka Shing Faculty of Medicine University of Hong Kong  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine Yuen Ling","family":"Au","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology, Department of Pathology, Queen Mary Hospital University of Hong Kong  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7363-0239","authenticated-orcid":false,"given":"William C. Y.","family":"Leung","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Queen Mary Hospital University of Hong Kong  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Hin Ian","family":"Leung","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Queen Mary Hospital University of Hong Kong  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/319760"},{"key":"e_1_2_9_3_1","unstructured":"Authority T. 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