{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:43:09Z","timestamp":1790289789764,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["26422"],"award-info":[{"award-number":["26422"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Psychological distresses and pre\u2010diabetes are among the risk factors of developing type\u2010II diabetes. The present study was conducted to determine the effectiveness of omega\u20103 and vitamin D co\u2010supplementation on psychological distresses in women of reproductive age with pre\u2010diabetes and hypovitaminosis D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The present factorial clinical trial was conducted on 168 women of reproductive age with pre\u2010diabetes and hypovitaminosis D. These participants were selected by stratified random sampling and were assigned to four groups for 8 weeks: group 1 (placebo group), group 2 (omega\u20103 group), group 3 (vitamin D group), and group 4 (co\u2010supplement group). The medication and placebo doses being two 1000\u2010mg tablets each day for omega\u20103 and 50,000\u2010IU pearls every 2 weeks for vitamin D. Fasting blood glucose and vitamin D were measured at the beginning of the study. The Depression Anxiety Stress Scale\u201021 and the Pittsburgh Sleep Quality Index were completed by the participants at the start and end of the intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant difference was observed in terms of reduction in anxiety and improvement in sleep quality in the co\u2010supplementation compared to the other three groups (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .05). There was also a significant difference between the group receiving both supplements and the group receiving only placebos in terms of reduction in depression and stress (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vitamin D and omega\u20103 co\u2010supplementation improved depression, anxiety, and sleep quality in women of reproductive age with pre\u2010diabetes and hypovitaminosis D. Therefore, these two supplements can be recommended for improving the mental health of this group of women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registry<\/jats:title>\n                    <jats:p>Iranian Registry of Clinical Trials Code: IRCT20100130003226N17. Registered on February 9, 2019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2342","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T08:31:58Z","timestamp":1630571518000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effect of omega\u20103 and vitamin D co\u2010supplementation on psychological distress in reproductive\u2010aged women with pre\u2010diabetes and hypovitaminosis D: A randomized controlled trial"],"prefix":"10.1002","volume":"11","author":[{"given":"Masoumeh","family":"Rajabi\u2010Naeeni","sequence":"first","affiliation":[{"name":"Department of Midwifery and Reproductive Health, Student Research Committee, School of Nursing and Midwifery Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1424-1951","authenticated-orcid":false,"given":"Mahrokh","family":"Dolatian","sequence":"additional","affiliation":[{"name":"Midwifery and Reproductive Health Research Center, Department of Midwifery and Reproductive Health, School of Nursing and Midwifery Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Qorbani","sequence":"additional","affiliation":[{"name":"Non\u2010communicable Diseases Research Center Alborz University of Medical Sciences  Karaj Iran"},{"name":"Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Abbas","family":"Vaezi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine School of Medicine Alborz University of Medical Sciences  Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"issue":"58","key":"e_1_2_8_2_1","first-page":"31","article-title":"Sleep parameters and the factors affecting the quality of sleep in patients attending selected clinics of Rasoul\u2010e\u2010Akram hospital","volume":"15","author":"Afkham Ebrahimi A.","year":"2008","journal-title":"Razi Journal of Medical Sciences"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010017\u20102068\u20106"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768\u2010200009001\u201000009"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13\u2010S067"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.111.106666"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/2251\u20106581\u201012\u201043"},{"issue":"15","key":"e_1_2_8_8_1","first-page":"3313","article-title":"Combination high\u2010dose omega\u20103 fatty acids and high\u2010dose cholecalciferol in new onset type 1 diabetes: A potential role in preservation of beta\u2010cell mass","volume":"20","author":"Baidal D. 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