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There were 386 EOAD and 399 LOAD cases. All individuals finished history inquiry, neurological examination, blood biochemical test, neuropsychological screening test, electroencephalography, brain CT\/MRI, and ApoE genotyping. Some participants had neuropsychological domain assessment (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0317), MRI morphometry (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0130), CSF testing of A\u03b242, p\u2010tau, t\u2010tau (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0144), or DNA sequencing (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0690). The variables were compared mainly between \u025b4 carriers and non\u2010carriers in EOAD and LOAD, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In LOAD, \u025b4 carriers showed female predominance; worse performance in trail making test, delayed recall of auditory verbal learning test (AVLT) and rey complex figure; smaller hippocampal, parahippocampal, and entorhinal volume, as compared to \u025b4 non\u2010carriers. In EOAD, \u025b4 carriers had lower scores in AVLT, episodic memory and modified Luria's tapping task; but less cortical atrophy in entorhinal, middle cingulate, inferior frontal, and parieto\u2010occipital regions, in comparison to \u025b4 non\u2010carriers. 6.2% (43\/690) subjects harbored potential causative mutations in APP, PSEN1, and PSEN2. In both EOAD and LOAD, no differences were observed between \u025b4 carriers and non\u2010carriers in CSF levels of A\u03b242, p\u2010tau, t\u2010tau, or mutation frequency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ApoE exerts a heterogeneous effect on clinical phenotypes in EOAD and LOAD, which might be related to the different genetic and pathological basis underlying them.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2373","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T20:33:42Z","timestamp":1632429222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of ApoE genotype on clinical phenotypes in early\u2010onset and late\u2010onset Alzheimer's disease in China: Data from the PUMCH dementia cohort"],"prefix":"10.1002","volume":"11","author":[{"given":"Liling","family":"Dong","sequence":"first","affiliation":[{"name":"Neurology Department State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Dongcheng Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Neurology Department State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Dongcheng Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6035-7456","authenticated-orcid":false,"given":"Caiyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Neurology Department State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Dongcheng Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenhui","family":"Mao","sequence":"additional","affiliation":[{"name":"Neurology Department State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Dongcheng Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Neurology Department State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Dongcheng Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Lei","sequence":"additional","affiliation":[{"name":"Neurology Department State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Dongcheng Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinying","family":"Huang","sequence":"additional","affiliation":[{"name":"Neurology Department State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Dongcheng Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Chu","sequence":"additional","affiliation":[{"name":"Neurology Department State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Dongcheng Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Radiology 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