{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:43:53Z","timestamp":1787165033431,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The purpose of this study was to investigate the relationship between pulsatility index (PI) or optic nerve sheath diameter (ONSD) and intracranial pressure (ICP) in patients with traumatic brain injury (TBI), and the ability of ONSD and ICP to predict intracranial hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 68 patients with TBI were included in this retrospective study. After receiving surgery treatment, they underwent transcranial Doppler ultrasound (TCD). The statistical correlation between PI or ONSD and ICP 1 week after surgery was analyzed. Furthermore, the areas under the curve (AUCs) of ONSD or PI or a combination of them were calculated to predict intracranial hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a correlation between ONSD and ICP. This correlation still remained at ONSD \u2265 5\u00a0mm. Furthermore, there was a strong correlation between PI and ICP. There was a moderate correlation between ICP and PI on days 3, 4, and 5 after surgery (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.508,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), and a strong correlation on days 6 and 7 after surgery (\n                      <jats:italic>r\u00a0<\/jats:italic>\n                      =\u00a00.645,\u00a0\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Moreover, for predicting\u00a0intracranial hypertension with PI \u2265 1.2\u00a0mm\u00a0or ONSD \u2265 5\u00a0mm or a combination of them, the AUC was 0.729, 0.900, and 0.943, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The correlation between ONSD or PI and invasive ICP was different with different levels of ICP in different periods in patients with TBI\u00a0after surgery. When ONSD\u00a0\u2265\u00a05\u00a0mm and PI\u00a0\u2265\u00a01.2, it could predict elevated ICP more accurately.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2396","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T02:50:22Z","timestamp":1635821422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Noninvasive evaluation of intracranial pressure in patients with traumatic brain injury by transcranial Doppler ultrasound"],"prefix":"10.1002","volume":"11","author":[{"given":"Tao","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Emergency The Second Affiliated Hospital of Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xigang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Second Affiliated Hospital of Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Second Affiliated Hospital of Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Second Affiliated Hospital of Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6688-1136","authenticated-orcid":false,"given":"Li","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Second Affiliated Hospital of Air 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