{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:46:52Z","timestamp":1793224012757,"version":"4.5.0"},"reference-count":75,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015592","name":"Canadian Institute for Military and Veteran Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["CX001600"],"award-info":[{"award-number":["CX001600"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01MH122774"],"award-info":[{"award-number":["K01MH122774"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 MH106574"],"award-info":[{"award-number":["R01 MH106574"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","award":["07040"],"award-info":[{"award-number":["07040"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["F31 MH113271"],"award-info":[{"award-number":["F31 MH113271"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K23MH112873"],"award-info":[{"award-number":["K23MH112873"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01\u2010MH043454"],"award-info":[{"award-number":["R01\u2010MH043454"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["T32\u2010MH018931"],"award-info":[{"award-number":["T32\u2010MH018931"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["T32MH13043"],"award-info":[{"award-number":["T32MH13043"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201010\u20101\u20100925"],"award-info":[{"award-number":["W81XWH\u201010\u20101\u20100925"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH08\u20102\u20100159"],"award-info":[{"award-number":["W81XWH08\u20102\u20100159"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DA 1222\/4\u20101"],"award-info":[{"award-number":["DA 1222\/4\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB\/TRR 58"],"award-info":[{"award-number":["SFB\/TRR 58"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["C07"],"award-info":[{"award-number":["C07"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["WA 1539\/8\u20102"],"award-info":[{"award-number":["WA 1539\/8\u20102"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["C06"],"award-info":[{"award-number":["C06"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000034","name":"Institute of Neurosciences, Mental Health and Addiction","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["W81XWH\u201008\u20102\u20100038"],"award-info":[{"award-number":["W81XWH\u201008\u20102\u20100038"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007229","name":"Bijzonder Onderzoeksfonds UGent","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates of brain age, compared to chronological age, may clarify the effects of PTSD on the brain and may inform treatment approaches targeting the neurobiology of aging in the context of PTSD.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n Adult subjects (\n N<\/jats:italic>\n \u00a0=\u00a02229; 56.2% male) aged 18\u201369 years (mean\u00a0=\u00a035.6, SD\u00a0=\u00a011.0) from 21 ENIGMA\u2010PGC PTSD sites underwent T1\u2010weighted brain structural magnetic resonance imaging, and PTSD assessment (PTSD+,\n n<\/jats:italic>\n \u00a0=\u00a0884). Previously trained voxel\u2010wise (brainageR) and region\u2010of\u2010interest (BARACUS and PHOTON) machine learning pipelines were compared in a subset of control subjects (\n n<\/jats:italic>\n \u00a0=\u00a0386). Linear mixed effects models were conducted in the full sample (those with and without PTSD) to examine the effect of PTSD on brain predicted age difference (brain PAD; brain age \u2212 chronological age) controlling for chronological age, sex, and scan site.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n BrainageR most accurately predicted brain age in a subset (\n n<\/jats:italic>\n \u00a0=\u00a0386) of controls (brainageR: ICC\u00a0=\u00a00.71,\n R<\/jats:italic>\n \u00a0=\u00a00.72, MAE\u00a0=\u00a05.68; PHOTON: ICC\u00a0=\u00a00.61,\n R<\/jats:italic>\n \u00a0=\u00a00.62, MAE\u00a0=\u00a06.37; BARACUS: ICC\u00a0=\u00a00.47,\n R<\/jats:italic>\n \u00a0=\u00a00.64, MAE\u00a0=\u00a08.80). Using brainageR, a three\u2010way interaction revealed that young males with PTSD exhibited higher brain PAD relative to male controls in young and old age groups; old males with PTSD exhibited lower brain PAD compared to male controls of all ages.\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n Differential impact of PTSD on brain PAD in younger versus older males may indicate a critical window when PTSD impacts brain aging, followed by age\u2010related brain changes that are consonant with individuals without PTSD. Future longitudinal research is warranted to understand how PTSD impacts brain aging across the lifespan.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/brb3.2413","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:51:52Z","timestamp":1639529512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1773-7733","authenticated-orcid":false,"given":"Ashley N.","family":"Clausen","sequence":"first","affiliation":[{"name":"VA Mid\u2010Atlantic Mental Illness Research Education, and Clinical Center Durham North Carolina USA"},{"name":"Duke University Brain Imaging and Analysis Center Durham North Carolina USA"},{"name":"Kansas City VA Medical Center Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelene A.","family":"Fercho","sequence":"additional","affiliation":[{"name":"Center for Brain and Behavior Research University of South Dakota Vermillion South Dakota USA"},{"name":"Civil Aerospace Medical Institute US Federal Aviation Administration Oklahoma City Oklahoma USA"},{"name":"Division of Basic Biomedical Sciences Sanford School of Medicine University of South Dakota Vermillion South Dakota USA"},{"name":"Sioux Falls VA Health Care System Sioux Falls South Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Monsour","sequence":"additional","affiliation":[{"name":"Duke University Brain Imaging and Analysis Center Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth","family":"Disner","sequence":"additional","affiliation":[{"name":"Center for Brain and Behavior Research University of South Dakota Vermillion South Dakota USA"},{"name":"Department of Psychiatry University of Minnesota Medical School Minneapolis Minnesota USA"},{"name":"Minneapolis VA Health Care System Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Salminen","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center Mark & Mary Stevens Neuroimaging & Informatics Institute Keck School of Medicine University of Southern California Marina del Rey California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney C.","family":"Haswell","sequence":"additional","affiliation":[{"name":"VA Mid\u2010Atlantic Mental Illness Research Education, and Clinical Center Durham North Carolina USA"},{"name":"Duke University Brain Imaging and Analysis Center Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Clarke","family":"Rubright","sequence":"additional","affiliation":[{"name":"VA Mid\u2010Atlantic Mental Illness Research Education, and Clinical Center Durham North Carolina USA"},{"name":"Duke University Brain Imaging and Analysis Center Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda A.","family":"Watts","sequence":"additional","affiliation":[{"name":"VA Mid\u2010Atlantic Mental Illness Research Education, and Clinical Center Durham North Carolina USA"},{"name":"Duke University Brain Imaging and Analysis Center Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Nicole","family":"Buckley","sequence":"additional","affiliation":[{"name":"VA Mid\u2010Atlantic Mental Illness Research Education, and Clinical Center Durham North Carolina USA"},{"name":"Duke University Brain Imaging and Analysis Center Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Maron\u2010Katz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Stanford University of Medicine Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Sierk","sequence":"additional","affiliation":[{"name":"University Medical Centre Charite Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Manthey","sequence":"additional","affiliation":[{"name":"University Medical Centre Charite Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Suarez\u2010Jimenez","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center Manhattan New York USA"},{"name":"New York State Psychiatric Institute New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bunmi O.","family":"Olatunji","sequence":"additional","affiliation":[{"name":"Department of Psychology Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7575-6142","authenticated-orcid":false,"given":"Christopher L.","family":"Averill","sequence":"additional","affiliation":[{"name":"Clinical Neuroscience Division National Center for PTSD West Haven Connecticut USA"},{"name":"Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology and Systems Neuroscience University of Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick J.","family":"Veltman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Amsterdam University Medical Centers Location VU University Medical Center VU University Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4617-8050","authenticated-orcid":false,"given":"Elizabeth A.","family":"Olson","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"McLean Hospital Belmont Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Chinese Academy of Sciences Beijing China"},{"name":"Laboratory for Traumatic Stress Studies CAS Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina L.","family":"Forster","sequence":"additional","affiliation":[{"name":"Brain Health Research Centre Department of Anatomy University of Otago Dunedin New Zealand"},{"name":"Division of Basic Biomedical Sciences Sanford School of Medicine University of South Dakota Vermillion South Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Walter","sequence":"additional","affiliation":[{"name":"University Medical Centre Charite Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6076-4067","authenticated-orcid":false,"given":"Jacklynn","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Marquette University Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Th\u00e9berge","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics University of Western Ontario London Ontario Canada"},{"name":"Department of Psychiatry Western University London Ontario Canada"},{"name":"Imaging Division Lawson Health Research Institute London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Simons","sequence":"additional","affiliation":[{"name":"Center for Brain and Behavior Research University of South Dakota Vermillion South Dakota USA"},{"name":"Sioux Falls VA Health Care System Sioux Falls South Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Bomyea","sequence":"additional","affiliation":[{"name":"UC San Diego Department of Psychiatry San Deigo California USA"},{"name":"VA San Diego Healthcare System Center of Excellence for Stress and Mental Health San Deigo California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie L.","family":"Frijling","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Amsterdam University Medical Centers Location Academic Medical Center Amsterdam Neuroscience University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Krystal","sequence":"additional","affiliation":[{"name":"Clinical Neuroscience Division National Center for PTSD West Haven Connecticut USA"},{"name":"Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin T.","family":"Baker","sequence":"additional","affiliation":[{"name":"Institute for Technology in Psychiatry McLean Hospital Harvard University Belmont Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Luan","family":"Phan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Health The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Ressler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Harvard Medical School Boston Massachusetts USA"},{"name":"Division of Depression and Anxiety Disorders McLean Hospital Belmont Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura K. M.","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Amsterdam University Medical Centers VU University Medical Center GGZ inGeest Amsterdam Neuroscience Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7183-8933","authenticated-orcid":false,"given":"Laura","family":"Nawijn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Amsterdam University Medical Centers Location Academic Medical Center Amsterdam Neuroscience University of Amsterdam Amsterdam The Netherlands"},{"name":"Department of Psychiatry Amsterdam University Medical Centers Location VU University Medical Center VU University Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5816-9181","authenticated-orcid":false,"given":"Lauren A. M.","family":"Lebois","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Harvard Medical School Boston Massachusetts USA"},{"name":"Division of Depression and Anxiety Disorders McLean Hospital Belmont Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianne","family":"Schmaal","sequence":"additional","affiliation":[{"name":"Centre for Youth Mental Health The University of Melbourne Melbourne Australia"},{"name":"Orygen The National Centre of Excellence in Youth Mental Health Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Densmore","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha E.","family":"Shenton","sequence":"additional","affiliation":[{"name":"Department of Psychiatry VA Boston Healthcare System Brockton Massachusetts USA"},{"name":"Departments of Psychiatry & Radiology Harvard Medical School Boston Massachusetts USA"},{"name":"Psychiatry Neuroimaging Laboratory Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"van Zuiden","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Amsterdam University Medical Centers Location Academic Medical Center Amsterdam Neuroscience University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray","family":"Stein","sequence":"additional","affiliation":[{"name":"UC San Diego Department of Family Medicine and Public Health San Deigo California USA"},{"name":"UC San Diego Department of Psychiatry San Deigo California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Fani","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca M.","family":"Simons","sequence":"additional","affiliation":[{"name":"Center for Brain and Behavior Research University of South Dakota Vermillion South Dakota USA"},{"name":"Department of Psychology University of South Dakota Vermillion South Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W. J.","family":"Neufeld","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Western University London Ontario Canada"},{"name":"Department of Psychiatry Western University London Ontario Canada"},{"name":"Department of Psychology University of British Columbia Okanagan Canada"},{"name":"Department of Psychology Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3758-1393","authenticated-orcid":false,"given":"Ruth","family":"Lanius","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Western University London Ontario Canada"},{"name":"Department of Psychiatry Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0160-7248","authenticated-orcid":false,"given":"Sanne","family":"van Rooij","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3628-6712","authenticated-orcid":false,"given":"Saskia B.J.","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Amsterdam University Medical Centers Location Academic Medical Center Amsterdam Neuroscience University of Amsterdam Amsterdam The Netherlands"},{"name":"Donders Institute for Brain Cognition and Behaviour Centre for Cognitive Neuroimaging Radboud University Nijmegen Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Bonomo","sequence":"additional","affiliation":[{"name":"New York State Psychiatric Institute New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6456-0053","authenticated-orcid":false,"given":"Tanja","family":"Jovanovic","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurosciences Wayne State University Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri","family":"deRoon\u2010Cassini","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Ely","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent A.","family":"Magnotta","sequence":"additional","affiliation":[{"name":"Departments of Radiology Psychiatry and Biomedical Engineering University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofu","family":"He","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center Manhattan New York USA"},{"name":"New York State Psychiatric Institute New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chadi G.","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Clinical Neuroscience Division National Center for PTSD West Haven Connecticut USA"},{"name":"Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA"},{"name":"Michael E DeBakey VA Medical Center Houston Texas USA"},{"name":"Menninger Department of Psychiatry Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Etkin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Stanford University of Medicine Stanford California USA"},{"name":"Wu Tsai Neuroscience Institute Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schmahl","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy Central Institute of Mental Health Medical Faculty Mannheim\/Heidelberg University Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Larson","sequence":"additional","affiliation":[{"name":"University of Wisconsin\u2010Milwaukee Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6988-3858","authenticated-orcid":false,"given":"Isabelle M.","family":"Rosso","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"McLean Hospital Belmont Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Urbano","family":"Blackford","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Vanderbilt University Medical Center Nashville Tennessee USA"},{"name":"Department of Veterans Affairs Tennessee Valley Healthcare System Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith K.","family":"Daniels","sequence":"additional","affiliation":[{"name":"University of Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Herzog","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy Central Institute of Mental Health Medical Faculty Mannheim\/Heidelberg University Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milissa L.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Division of Women's Mental Health McLean Hospital Belmont Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Olff","sequence":"additional","affiliation":[{"name":"ARQ National Psychotrauma Centrum Diemen The Netherlands"},{"name":"Department of Psychiatry Amsterdam University Medical Centers Location Academic Medical Center Amsterdam Neuroscience University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Center for Healthy Minds Departments of Psychology and Psychiatry University of Wisconsin\u2010Madison Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott R.","family":"Sponheim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Minnesota Medical School Minneapolis Minnesota USA"},{"name":"Minneapolis VA Health Care System Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven C.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Experimental Clinical and Health Psychology Ghent University Ghent Belgium"},{"name":"Department of Personality Psychological Assessment and Treatment University of Deusto Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Straube","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology and Systems Neuroscience University of Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center Manhattan New York USA"},{"name":"New York State Psychiatric Institute New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuval","family":"Neria","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center Manhattan New York USA"},{"name":"New York State Psychiatric Institute New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee A.","family":"Baugh","sequence":"additional","affiliation":[{"name":"Center for Brain and Behavior Research University of South Dakota Vermillion South Dakota USA"},{"name":"Division of Basic Biomedical Sciences Sanford School of Medicine University of South Dakota Vermillion South Dakota USA"},{"name":"Sioux Falls VA Health Care System Sioux Falls South Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"Cole","sequence":"additional","affiliation":[{"name":"Centre for Medical Image Computing Computer Science University College London London UK"},{"name":"Dementia Research Centre Institute of Neurology University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center Mark & Mary Stevens Neuroimaging & Informatics Institute Keck School of Medicine University of Southern California Marina del Rey California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendra A.","family":"Morey","sequence":"additional","affiliation":[{"name":"VA Mid\u2010Atlantic Mental Illness Research Education, and Clinical Center Durham North Carolina USA"},{"name":"Duke University Brain Imaging and Analysis Center Durham North Carolina USA"},{"name":"Kansas City VA Medical Center Kansas City Missouri USA"},{"name":"ARQ National Psychotrauma Centrum Diemen The Netherlands"},{"name":"Department of Psychiatry Amsterdam University Medical Centers VU University Medical Center GGZ inGeest Amsterdam Neuroscience Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2016.01.024"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00115"},{"issue":"2","key":"e_1_2_8_4_1","first-page":"490","article-title":"Beck depression inventory\u2010II","volume":"78","author":"Beck A. T.","year":"1996","journal-title":"San Antonio"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2134(02)00541-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.22059"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2019.06.001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6394(2000)12:1<1::AID-DA1>3.0.CO;2-W"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.07.002"},{"issue":"4","key":"e_1_2_8_10_1","first-page":"14","article-title":"Post\u2010traumatic stress disorder and acute stress disorder I: Their nature and assessment considerations","volume":"2","author":"Cahill S. P.","year":"2005","journal-title":"Psychiatry"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0539-9"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199509000-00002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004601"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2020.03.014"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2017.10.001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-24970-0_19"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.07.059"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.62"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874609811003010003"},{"key":"e_1_2_8_20_1","unstructured":"Davidson J. R.(1996).Davidson trauma scale (DTS)."},{"issue":"3","key":"e_1_2_8_21_1","doi-asserted-by":"crossref","first-page":"e0121945","DOI":"10.1371\/journal.pone.0121945","article-title":"Cocor: A comprehensive solution for the statistical comparison of correlations","volume":"10","author":"Diedenhofen B.","year":"2015","journal-title":"PLOS One"},{"key":"e_1_2_8_22_1","volume-title":"The master algorithm: How the quest for the ultimate learning machine will remake our world","author":"Domingos P.","year":"2015"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194144"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301412"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)30377-7"},{"key":"e_1_2_8_26_1","first-page":"3829","article-title":"Brain\u2010age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort","author":"Elliott M. L.","year":"2019","journal-title":"Molecular Psychiatry"},{"key":"e_1_2_8_27_1","volume-title":"Structured clinical interview for DSM\u20105 disorders\u2013research version (SCID\u20105\u2010RV)","author":"First M.","year":"2014"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2007.27"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00789"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067346"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.06.003"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1077801206294534"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5103"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbx172"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0754-0"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.03.004"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13163-9"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3520-09.2009"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-0700-5"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.593"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0019362"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbt142"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3928\/0048-5713-20020901-06"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00317"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.03.048"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24588"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.11.005"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.09.006"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(94)00075-U"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.22075"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-14-10"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/HRP.0000000000000167"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.111"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2019.11.016"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2014.03.009"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(198601)42:1<28::AID-JCLP2270420104>3.0.CO;2-T"},{"key":"e_1_2_8_57_1","volume-title":"Structured interview for DSM\u2010IV personality: Sidp\u2010IV","author":"Pfohl B.","year":"1997"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-813176-3.00041-9"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12514"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.15070922"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0298-z"},{"issue":"9","key":"e_1_2_8_62_1","first-page":"93","article-title":"Status update on the Sheehan\u2010suicidality tracking scale (S\u2010STS) 2014","volume":"11","author":"Sheehan D. V.","year":"2014","journal-title":"Innovations in Clinical Neuroscience"},{"key":"e_1_2_8_63_1","unstructured":"Sheehan D. &Lecrubier Y.(2010). The mini\u2010international neuropsychiatric interview version 6.0 (MINI 6.0).Medical Outcomes System Inc.: Jacksonville FL."},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.05.029"},{"key":"e_1_2_8_65_1","first-page":"547","volume-title":"Hospital anxiety and depression scale (HADS). Handbook of psychiatric measures","author":"Snaith R.","year":"2000"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2009.06.002"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820080032005"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-7967(98)00087-4"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00090"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2006.06.009"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1037\/pas0000486"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2017.12.007"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-017-0823-5"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.3928\/00485713-20160729-01"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0755-z"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.18060\/1874"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.2413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.2413","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.2413","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.2413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T23:53:24Z","timestamp":1693094004000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.2413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,14]]},"references-count":75,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/brb3.2413"],"URL":"https:\/\/doi.org\/10.1002\/brb3.2413","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.2413\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2413\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2413\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2413\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2413\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,14]]},"assertion":[{"value":"2021-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2413"}}