{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T21:07:16Z","timestamp":1781298436122,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>For detecting mild cognitive impairment (MCI), brief cognitive screening tools are increasingly required for the advantage of time saving and no need for special equipment or trained raters. We aimed to develop a modified Chinese version of Mini\u2010Addenbrooke's Cognitive Examination (C\u2010MACE) and further evaluate its validation in detecting MCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 716 individuals aged from 50 to 90 years old were recruited, including 431 cognitively normal controls (NC) and 285 individuals with MCI. The effect size of Cramer's V was used to explore which items in the Chinese version of Addenbrooke's Cognitive Examination\u2010III (ACE\u2010III\u2010CV) best associated with MCI and to form the C\u2010MACE. Receiver operating characteristic (ROC) analyses were carried out to explore the ability of C\u2010MACE, ACE\u2010III\u2010CV, Chinese version of Montreal Cognitive Assessment\u2010Basic (MoCA\u2010BC), and Mini\u2010Mental State Examination (MMSE) in discriminating MCI from NC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five items with greatest effect sizes of Cramer's V were selected from ACE\u2010III\u2010CV to form the C\u2010MACE: Memory Immediate Recall, Memory Delayed Recall, Memory Recognition, Verbal Fluency Animal and Language Naming. With a total score of 38, the C\u2010MACE had a satisfactory classification accuracy in detecting MCI (area under the ROC curve, AUC\u00a0=\u00a00.892), superior to MMSE (AUC\u00a0=\u00a00.782) and comparable to ACE\u2010III\u2010CV (AUC\u00a0=\u00a00.901) and MoCA\u2010BC (AUC\u00a0=\u00a00.916). In the subgroup of Age\u00a0&gt;\u00a070 years, Education \u2264 12 years, the C\u2010MACE got a highest classification accuracy (AUC\u00a0=\u00a00.958) for detecting MCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the Chinese\u2010speaking population, C\u2010MACE derived from ACE\u2010III\u2010CV may identify MCI with a good classification accuracy, especially in aged people with low education.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.2418","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T16:30:42Z","timestamp":1638203442000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Validation of a modified Chinese version of Mini\u2010Addenbrooke's Cognitive Examination for detecting mild cognitive impairment"],"prefix":"10.1002","volume":"12","author":[{"given":"Feng\u2010Feng","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Gerontology Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Gerontology Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gerontology Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5079-8047","authenticated-orcid":false,"given":"Qi\u2010Hao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gerontology Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.3_Part_1.515"},{"key":"e_1_2_8_4_1","article-title":"Addenbrooke's Cognitive Examination III (ACE\u2010III) and mini\u2010ACE for the detection of dementia and mild cognitive impairment","volume":"12","author":"Beishon L. 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