{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:30:33Z","timestamp":1792873833367,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T00:00:00Z","timestamp":1638057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objects<\/jats:title>\n                    <jats:p>Abnormal blood pressure (BP) regulation is a feature of autonomic dysfunction in Parkinson's disease (PD) patients. The present study was to analyze the BP alterations by 24\u2010h ambulatory BP monitoring in PD patients with different disease stages and subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>32 consecutive patients PD patients and 43 control patients in our hospital from 2017 to 2020 were included. The circadian BP rhythm was divided into three types according to the 24\u2010h ambulatory BP monitoring. Dipping was defined as an average systolic BP (SBP) reduction during night\u2010time of 10%\u201319%. Reverse dipping was defined as an average increase in night\u2010time SBP values. The differences of the circadian BP rhythm and BP variability (BPV) were analyzed between PD group and the control group, the early PD group and the advanced PD group, as well as the tremor\u2010dominant group and the nontremor\u2010dominant group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was statistical difference in circadian BP rhythm between PD group and control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). There were statistical differences in circadian BP rhythm between the early PD group and the advanced PD group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). The mean values of night\u2010time SBP and diastolic BP (DBP) in the advanced PD group were higher than those in the control group and the early PD group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). The DBP CV in the advanced PD group was higher than that in the control group and the early PD group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). There was no significant difference of circadian BP rhythm, mean BP, and BPV between the tremor\u2010dominant and the nontremor\u2010dominant PD group after matching the disease duration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Reverse dipping was more common in PD patients in this study, especially in the advanced PD patients. 24\u2010h ambulatory BP monitoring is an important method to evaluate the BP alterations in PD patients. Clinicians should be alert to reverse dipping in PD patients and intervene to prevent serious clinical events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2428","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T02:55:03Z","timestamp":1638154503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["24\u2010hour ambulatory blood pressure alterations in patients with Parkinson's disease"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5576-1937","authenticated-orcid":false,"given":"Liwei","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Neurology Shanghai Fifth People's Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Shanghai Fifth People's Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenmei","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurology Shanghai Fifth People's Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Shanghai Fifth People's Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Health Statistics Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danhong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology Shanghai Fifth People's Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-303135"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-019-01113-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2006.02.020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30079-5"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7339-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2009.08.007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12338"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006895","article-title":"24\u2010hour blood pressure variability assessed by average real variability: A systematic review and meta\u2010analysis","volume":"6","author":"Luis J. 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