{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:02:15Z","timestamp":1772118135916,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Published researches have suggested some associations between PPAR\u2010\u03b3 and ischemic stroke (IS) development. This meta\u2010analysis was conducted to evaluate the association between PPAR\u2010\u03b3 gene polymorphisms and IS risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A systematic search was conducted in PubMed, Embase, Web of Science, China National Knowledge Infrastructure, and WanFang databases. The pooled association of odd ratios (ORs) and its 95% confidence interval (CI) was calculated to assess the IS risk of PPAR\u2010\u03b3 rs1801282 C\/G and rs3856806 C\/T polymorphisms. Furthermore, the heterogeneity test, cumulative analyses, sensitivity analyses, and publication bias were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      Sixteen publications with 3786 cases and 5343 controls were identified. Overall findings indicated that rs1801282 C\/G polymorphism may be associated with an increased risk for IS (GG vs. CC: OR\u00a0=\u00a02.17 95%CI\u00a0=\u00a01.09\u20134.35,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.03,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2\u00a0<\/jats:sup>\n                      =\u00a00%; GG vs. CC+CG: OR\u00a0=\u00a02.15, 95%CI\u00a0=\u00a01.07\u20134.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.03,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2\u00a0<\/jats:sup>\n                      =\u00a00%). The similar results were also found in the subgroup analysis. In addition, no significant association was observed between rs3856806 C\/T polymorphism and IS risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, our study showed that PPAR\u2010\u03b3 rs1801282 C\/G polymorphism probably plays an important role in IS occurrence. The result should be verified with more studies in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2434","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T16:49:24Z","timestamp":1636562964000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Relationship between PPAR\u2010\u03b3 gene polymorphisms and ischemic stroke risk: A meta\u2010analysis"],"prefix":"10.1002","volume":"11","author":[{"given":"Fan","family":"Cheng","sequence":"first","affiliation":[{"name":"Center of Cardiopulmonary Rehabilitation Taihe Hospital Hubei University of Medicine  Shiyan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Min","family":"Si","sequence":"additional","affiliation":[{"name":"Center of Cardiopulmonary Rehabilitation Taihe Hospital Hubei University of Medicine  Shiyan China"},{"name":"Department of Neurology Taihe Hospital Hubei Key Laboratory of Embryonic Stem Cell Research Hubei University of Medicine  Shiyan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gong\u2010Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shenzhen University General Hospital Shenzhen University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2800-855X","authenticated-orcid":false,"given":"Lan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center of Cardiopulmonary Rehabilitation Taihe Hospital Hubei University of Medicine  Shiyan China"},{"name":"Department of Neurology Taihe Hospital Hubei Key Laboratory of Embryonic Stem Cell Research Hubei University of Medicine  Shiyan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2015.02.003"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/vhrm.s2397"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031\u2010014\u20100326\u20103"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(19)30034\u20101"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/3099"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(09)70025\u20100"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010557"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2478\/bjmg\u20102018\u20100011"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1006\u20103110.2007.02.011"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2019.03.010"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305378"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975\u2010017\u20100577\u20108"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1179\/016164107X172347"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.08.024"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.11.027"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001360"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.4238\/gmr.15027332"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010693.pub5"},{"issue":"3","key":"e_1_2_10_20_1","first-page":"3595","article-title":"Relationship between PPAR7 C161T gene polymorphisms and atherosclerotic cerebral infarction (Chinese)","volume":"20","author":"Liu Z. 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