{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:41:43Z","timestamp":1792518103096,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010876","name":"Shanghai University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["Y2021002"],"award-info":[{"award-number":["Y2021002"]}],"id":[{"id":"10.13039\/501100010876","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Knee osteoarthritis (KOA) is characterized by a degenerative change of knee cartilage and secondary bone hyperplasia, resulting in pain, stiffness, and abnormal walking gait. Long\u2010term chronic pain causes considerable cortical plasticity alternations in patients. However, the brain structural and functional alterations associated with the pathological changes in knee joints of end\u2010stage KOA patients remain unclear. This study aimed to analyze the structural and functional connectivity alterations in end\u2010stage KOA to comprehensively understand the main brain\u2010associated mechanisms underlying its development and progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, 37 patients with KOA and 37 demographically matched healthy controls (HCs) were enrolled. Alternations in gray matter (GM) volume in patients with KOA were determined using voxel\u2010based morphometry. The region with the largest GM volume alteration was selected as the region of interest to calculate the voxel\u2010wise resting\u2010state functional connectivity (rs\u2010FC) in the two groups. Pearson's correlation coefficient was used to analyze the correlation between clinical measures and GM volume alternations in patients with KOA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with HCs, patients with KOAs exhibited significantly decreased GM volumes in the left middle temporal gyrus (left\u2010MTG) and the left inferior temporal gyrus. Results of the voxel\u2010wise rs\u2010FC analysis revealed that compared with HCs, patients with KOA had decreased left\u2010MTG rs\u2010FC to the right dorsolateral superior frontal gyrus, left middle frontal gyrus, and left medial superior frontal gyrus. GM volume in the left\u2010MTG was negatively correlated with the Western Ontario and McMaster Universities Arthritis Index in patients with KOA (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.393,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.016).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Structural remodeling and functional connectivity alterations may be one of the central brain mechanisms associated with end\u2010stage KOA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2479","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T01:45:25Z","timestamp":1640828725000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Altered brain activity in end\u2010stage knee osteoarthritis revealed by resting\u2010state functional magnetic resonance imaging"],"prefix":"10.1002","volume":"12","author":[{"given":"Bing\u2010Xin","family":"Kang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Henan University of Chinese Medicine  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Science Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Shen","sequence":"additional","affiliation":[{"name":"Guanghua Hospital Shanghai University of Traditional Chinese Medicine  Shanghai China"},{"name":"Arthritis Institute of Integrated Traditional Chinese and Western Medicine Shanghai Academy of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine, Shanghai, 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Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Zhong","sequence":"additional","affiliation":[{"name":"Guanghua Hospital Shanghai University of Traditional Chinese Medicine  Shanghai China"},{"name":"Arthritis Institute of Integrated Traditional Chinese and Western Medicine Shanghai Academy of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Xin","family":"Gao","sequence":"additional","affiliation":[{"name":"Guanghua Hospital Shanghai University of Traditional Chinese Medicine  Shanghai China"},{"name":"Arthritis Institute of Integrated Traditional Chinese and Western Medicine Shanghai Academy of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine, Shanghai, 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