{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:00:32Z","timestamp":1787061632614,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T00:00:00Z","timestamp":1405641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG03438501"],"award-info":[{"award-number":["AG03438501"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["T32 NS048005"],"award-info":[{"award-number":["T32 NS048005"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2014,9]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n To determine whether a polygenic risk score for Alzheimer's disease (\n AD<\/jats:styled-content>\n ) predicts dementia probability and memory functioning in non\u2010Hispanic black (\n NHB<\/jats:styled-content>\n ) and non\u2010Hispanic white (\n NHW<\/jats:styled-content>\n ) participants from a sample not used in previous genome\u2010wide association studies.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Non\u2010Hispanic white and\n NHB<\/jats:styled-content>\n Health and Retirement Study (\n HRS<\/jats:styled-content>\n ) participants provided genetic information and either a composite memory score (\n n<\/jats:italic>\n \u00a0=\u00a010,401) or a dementia probability score (\n n<\/jats:italic>\n \u00a0=\u00a07690). Dementia probability score was estimated for participants' age 65+ from 2006 to 2010, while memory score was available for participants age 50+. We calculated\n AD<\/jats:styled-content>\n genetic risk scores (\n AD<\/jats:styled-content>\n \u2010\n GRS<\/jats:styled-content>\n ) based on 10 polymorphisms confirmed to predict\n AD<\/jats:styled-content>\n , weighting alleles by beta coefficients reported in AlzGene meta\u2010analyses. We used pooled logistic regression to estimate the association of the\n AD<\/jats:styled-content>\n \u2010\n GRS<\/jats:styled-content>\n with dementia probability and generalized linear models to estimate its effect on memory score.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Each 0.10 unit change in the\n AD<\/jats:styled-content>\n \u2010\n GRS<\/jats:styled-content>\n was associated with larger relative effects on dementia among\n NHW<\/jats:styled-content>\n aged 65+ (\n OR<\/jats:styled-content>\n \u00a0=\u00a02.22; 95%\n CI<\/jats:styled-content>\n : 1.79, 2.74;\n P<\/jats:italic>\n \u00a0<\u00a00.001) than\n NHB<\/jats:styled-content>\n (\n OR<\/jats:styled-content>\n =1.33; 95%\n CI<\/jats:styled-content>\n : 1.00, 1.77;\n P<\/jats:italic>\n \u00a0=\u00a00.047), although additive effect estimates were similar. Each 0.10 unit change in the\n AD<\/jats:styled-content>\n \u2010\n GRS<\/jats:styled-content>\n was associated with a \u22120.07 (95%\n CI<\/jats:styled-content>\n : \u22120.09, \u22120.05;\n P<\/jats:italic>\n \u00a0<\u00a00.001)\n SD<\/jats:styled-content>\n difference in memory score among\n NHW<\/jats:styled-content>\n aged 50+, but no significant differences among\n NHB<\/jats:styled-content>\n (\n \u03b2\u00a0<\/jats:italic>\n =\u00a0\u22120.01; 95%\n CI<\/jats:styled-content>\n : \u22120.04, 0.01;\n P<\/jats:italic>\n \u00a0=\u00a00.546). [Correction added on 29 July 2014, after first online publication: confidence intervals\nhave been amended.] The estimated effect of the\n GRS<\/jats:styled-content>\n was significantly smaller among\n NHB<\/jats:styled-content>\n than\n NHW<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u00a0<\u00a00.05) for both outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This analysis provides evidence for differential relative effects of the\n GRS<\/jats:styled-content>\n on dementia probability and memory score among\n NHW<\/jats:styled-content>\n and\n NHB<\/jats:styled-content>\n in a new, national data set.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/brb3.248","type":"journal-article","created":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T07:53:44Z","timestamp":1405670024000},"page":"687-697","source":"Crossref","is-referenced-by-count":62,"title":["Validation of a polygenic risk score for dementia in black and white individuals"],"prefix":"10.1002","volume":"4","author":[{"given":"Jessica R.","family":"Marden","sequence":"first","affiliation":[{"name":"Department of Social and Behavioral Sciences Harvard School of Public Health 677 Huntington Ave Boston Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Social and Behavioral Sciences Harvard School of Public Health 677 Huntington Ave Boston Massachusetts 02115"},{"name":"Department of Epidemiology and Biostatistics University of California at San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Tchetgen Tchetgen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Harvard School of Public Health 677 Huntington Ave Boston Massachusetts 02115"},{"name":"Department of Epidemiology Harvard School of Public Health 677 Huntington Ave Boston Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Kawachi","sequence":"additional","affiliation":[{"name":"Department of Social and Behavioral Sciences Harvard School of Public Health 677 Huntington Ave Boston Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Maria","family":"Glymour","sequence":"additional","affiliation":[{"name":"Department of Social and Behavioral Sciences Harvard School of Public Health 677 Huntington Ave Boston Massachusetts 02115"},{"name":"Department of Epidemiology and Biostatistics University of California at San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24135"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342778"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988710383571"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1934"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05913"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm092"},{"key":"e_1_2_7_8_1","first-page":"209","article-title":"Survey design and methodology in the Health and Retirement Study and the Wisconsin Longitudinal Study","volume":"30","author":"Hauser R. M.","year":"2004","journal-title":"Popul. Dev. Rev."},{"key":"e_1_2_7_9_1","unstructured":"Health and Retirement Study.2010.Genome Wide Association Study Overview."},{"key":"e_1_2_7_10_1","unstructured":"Health and Retirement Study.2011.Sample Size and Response Rates."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.7826\/ISR-UM.06.585031.001.05.0001.1995"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370123"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170002691X"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291799002299"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2307\/146277"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115107"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087448"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370217"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.3507"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","unstructured":"Ofstedal M. B. G. G.Fisher andA. R.Herzog.2005.Documentation of cognitive functioning measures in the Health and Retirement Study.Univ. of Michigan Ann Arbor MI.","DOI":"10.7826\/ISR-UM.06.585031.001.05.0010.2005"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.1998.tb00087.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380319"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22362"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2973"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/17.4.955"},{"key":"e_1_2_7_26_1","first-page":"574","article-title":"Relative risk of Alzheimer disease and age\u2010at\u2010onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City","volume":"58","author":"Tang M.\u2010X.","year":"1996","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.10.751"},{"key":"e_1_2_7_28_1","volume-title":"Quality control report for genotypic data","author":"Weir D.","year":"2012"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70286-6"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e31826cfe90"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.60.110707.163625"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbrb3.248","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.248","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.248","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:53:31Z","timestamp":1696607611000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,18]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1002\/brb3.248"],"URL":"https:\/\/doi.org\/10.1002\/brb3.248","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,18]]}}}