{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T20:59:22Z","timestamp":1781125162908,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to investigate the alterations in whole\u2010brain gray matter density in early stage type 2 diabetes mellitus (T2DM) patients with cognitive impairment using magnetic resonance imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010six cases of early stage T2DM patients with cognitive impairment (T2DM\u2010CI), 34 cases of early stage T2DM patients without cognitive impairment (T2DM) and 30 cases of healthy controls (HC) were enrolled. Montreal Cognitive Assessment (MoCA) and Mini\u2010Mental State Examination (MMSE) scores were used to identify the cognitive impairment. The whole\u2010brain gray matter density was analyzed using 3D\u2010T1 BRAVO imaging, using the voxel\u2010based morphometry method on T1 structure imaging of two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The correlation analysis of total gray matter density with MMSE and MoCA scores in the T2DM\u2010CI group was performed. There were no significant differences in MMSE and MoCA scores between the HC and T2DM groups. However, the MMSE and MoCA scores in the T2DM\u2010CI group were significantly reduced compared with the T2DM group. There were no significant differences in age, gender, education, body mass index (BMI) or blood pressure among the three groups. Voxel\u2010based morphometry (VBM) results showed that the density of left triangle part of inferior frontal gyrus, orbital part of inferior frontal gyrus and opercular part of inferior frontal gyrus and left insula in the T2DM\u2010CI group decreased compared with the T2DM group. Correlation analysis results showed that there was a significant positive correlation between total gray matter density and scores of MMSE and MoCA scores in the T2DM\u2010CI group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, total gray matter density is positively correlated with the scores of MMSE and MoCA in T2DM patients, which may be an early sign of cognitive impairment in patients with T2DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2497","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T06:40:50Z","timestamp":1644388850000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The whole\u2010brain voxel\u2010based morphometry study in early stage of T2DM patients"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1399-6217","authenticated-orcid":false,"given":"Yana","family":"He","sequence":"first","affiliation":[{"name":"Department of Medical Imaging First Teaching Hospital of Tianjin University of Traditional Chinese Medicine  Tianjin China"},{"name":"National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging First Teaching Hospital of Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging First Teaching Hospital of Tianjin University of Traditional Chinese Medicine  Tianjin China"},{"name":"National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0582"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168\u20108227(03)00084\u20106"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317518778513"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.03.015"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.12.043"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13\u20101219"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007020050067"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.006"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55090546"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24617"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0255-z"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1283"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00856"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3197"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010160715"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00161"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00107"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2939528"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335876"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13\u20100143"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12\u20100746"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.04.016"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000080939.39414.83"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.139482"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm105"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2017.09.001"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.37175\/stemedicine.v2i7.91"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.06.062"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.37175\/stemedicine.v2i5.73"},{"key":"e_1_2_8_31_1","first-page":"15383","article-title":"Gray matter atrophy in patients with Parkinson's disease and those with mild cognitive impairment: A voxel\u2010based morphometry study","volume":"8","author":"Zhang J.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.01.006"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0284185114533329"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.2497","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.2497","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.2497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:01:06Z","timestamp":1692316866000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.2497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,9]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/brb3.2497"],"URL":"https:\/\/doi.org\/10.1002\/brb3.2497","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.2497\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2497\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2497\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2497\/v1\/review1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,9]]},"assertion":[{"value":"2021-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2497"}}