{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:02:08Z","timestamp":1791302528001,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T00:00:00Z","timestamp":1407196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2009\/06686-6"],"award-info":[{"award-number":["2009\/06686-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2009\/05565-0"],"award-info":[{"award-number":["2009\/05565-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>G\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> has been shown to decrease inflammatory processes and to act positively on the process of peripheral nerve regeneration during the course of muscular dystrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aims of this study were to investigate the effects of treatment of G\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> during sciatic nerve regeneration and histological analysis in the soleus muscle in <jats:styled-content style=\"fixed-case\">MDX<\/jats:styled-content> mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six\u2010week\u2010old male <jats:styled-content style=\"fixed-case\">MDX<\/jats:styled-content> mice underwent left sciatic nerve crush and were G\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> treated at 7\u00a0days prior to and 21\u00a0days after crush. Ten and twenty\u2010one days after surgery, the mice were euthanized, and the sciatic nerves were processed for immunohistochemistry (anti\u2010p75<jats:styled-content style=\"fixed-case\"><jats:sup>NTR<\/jats:sup><\/jats:styled-content> and anti\u2010neurofilament) and transmission electron microscopy. The soleus muscles were dissected out and processed for H&amp;E staining and subsequent morphologic analysis. Motor function analyses were performed at 7\u00a0days prior to and 21\u00a0days after sciatic crush using the CatWalk system and the sciatic nerve index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups treated with G\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> showed increased p75<jats:styled-content style=\"fixed-case\"><jats:sup>NTR<\/jats:sup><\/jats:styled-content> and neurofilament expression after sciatic crush. G\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> treatment decreased the number of degenerated and regenerated muscle fibers, thereby increasing the number of normal muscle fibers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The reduction in p75<jats:styled-content style=\"fixed-case\"><jats:sup>NTR<\/jats:sup><\/jats:styled-content> and neurofilament indicates a decreased regenerative capacity in <jats:styled-content style=\"fixed-case\">MDX<\/jats:styled-content> mice following a lesion to a peripheral nerve. The reduction in motor function in the crushed group compared with the control groups may reflect the cycles of muscle degeneration\/regeneration that occur postnatally. Thus, G\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> treatment increases motor function in <jats:styled-content style=\"fixed-case\">MDX<\/jats:styled-content> mice. Nevertheless, the decrease in baseline motor function in these mice is not reversed completely by G\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.250","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T11:41:35Z","timestamp":1407238895000},"page":"738-753","source":"Crossref","is-referenced-by-count":17,"title":["Granulocyte colony\u2010stimulating factor (G\u2010<scp>CSF<\/scp>) positive effects on muscle fiber degeneration and gait recovery after nerve lesion in <scp>MDX<\/scp> mice"],"prefix":"10.1002","volume":"4","author":[{"given":"Gustavo F.","family":"Sim\u00f5es","sequence":"first","affiliation":[{"name":"Departament of Structural and Functional Biology Institute of Biology University of Campinas (UNICAMP) CP 6109 CEP 13083\u2010907 Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana U.","family":"Benitez","sequence":"additional","affiliation":[{"name":"Departament of Structural and Functional Biology Institute of Biology University of Campinas (UNICAMP) CP 6109 CEP 13083\u2010907 Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre L. 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