{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:01:06Z","timestamp":1780614066640,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Backgrounds<\/jats:title>\n                    <jats:p>\n                      Although the short\u2010term efficacy of bilateral subthalamic deep brain stimulation (DBS) has been reported in a limited number of Parkinson's disease (PD) patients with\n                      <jats:italic>SNCA<\/jats:italic>\n                      mutations, there are no data for long\u2010term outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This multicenter retrospective study investigated previously reported PD patients with\n                      <jats:italic>SNCA<\/jats:italic>\n                      mutations, implanted with bilateral subthalamic DBS. We compared demographic and clinical data at baseline and last follow\u2010up. Clinical data of motor and nonmotor symptoms and motor fluctuation were collected up to 10\u00a0years from DBS surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among four subjects, three had\n                      <jats:italic>SNCA<\/jats:italic>\n                      duplication and one had c.158C.A (p.A53E) mutation. The mean post\u2010implantation follow\u2010up duration was 5.4\u00a0\u00b1 3.7 years. All patients with\n                      <jats:italic>SNCA<\/jats:italic>\n                      duplication showed favorable outcome, although one died from breast cancer 1.5 years after DBS. The patient with the missense mutation became wheelchair\u2010bound due to progressed axial, cognitive and psychiatric symptoms after 3.5 years from DBS despite the benefit on motor fluctuation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Based on findings in our small cohort, subthalamic DBS could be beneficial for motor fluctuation in PD patients with\n                      <jats:italic>SNCA<\/jats:italic>\n                      mutations, especially those with\n                      <jats:italic>SNCA<\/jats:italic>\n                      duplication, and cognitive and psychiatric symptoms are important for the long\u2010term outcome of subthalamic DBS.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2503","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T05:28:29Z","timestamp":1642483709000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Subthalamic deep brain stimulation in Parkinson's disease with\n                    <i>SNCA<\/i>\n                    mutations: Based on the follow\u2010up to 10\u00a0years"],"prefix":"10.1002","volume":"12","author":[{"given":"Jinyoung","family":"Youn","sequence":"first","affiliation":[{"name":"Departments of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"},{"name":"Neuroscience Center Samsung Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7985-5367","authenticated-orcid":false,"given":"Genko","family":"Oyama","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutaka","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Shimo","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomi","family":"Kuusim\u00e4ki","sequence":"additional","affiliation":[{"name":"Neurocenter Turku University Hospital  Turku Finland"},{"name":"Clinical Neurosciences, Faculty of Medicine University of 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Il","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Rae","family":"Cho","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery Konkuk University Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9145-6729","authenticated-orcid":false,"given":"Jin Whan","family":"Cho","sequence":"additional","affiliation":[{"name":"Departments of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"},{"name":"Neuroscience Center Samsung Medical Center  Seoul Republic of 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