{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:49:52Z","timestamp":1774464592095,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Prolonged febrile seizures (FS) are a risk factor for the development of hippocampal\u2010associated temporal lobe epilepsy. The dentate gyrus is the major gateway to the hippocampal network and one of the sites in the brain where neurogenesis continues postnatally. Previously, we found that experimental FS increase the survival rate and structural integration of newborn dentate granule cells (DGCs). In addition, mature post\u2010FS born DGCs express an altered receptor panel. Here, we aimed to study if these molecular and structural changes are accompanied by an altered cellular functioning. Experimental FS were induced by hyperthermia in 10\u2010days\u2010old Sprague\u2010Dawley rats. Proliferating progenitor cells were labeled the next day by injecting green fluorescent protein expressing retroviral particles bilaterally in the dentate gyri. Eight weeks later, spontaneous excitatory and inhibitory postsynaptic events (sEPSCs and sIPSCs, respectively) were recorded from labeled DGCs using the whole\u2010cell patch\u2010clamp technique. Experimental FS resulted in a robust decrease of the inter event interval (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.0001) and a small decrease of the amplitude of sEPSCs (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.001). Collectively the spontaneous excitatory charge transfer increased (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.01). Experimental FS also slightly increased the frequency of sIPSCs (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.05), while the amplitude of these events decreased strongly (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.0001). The net inhibitory charge transfer remained unchanged. Experimental, early\u2010life FS have a long\u2010term effect on post\u2010FS born DGCs, as they display an increased spontaneous excitatory input when matured. It remains to be established if this presents a mechanism for FS\u2010induced epileptogenesis.\n                  <\/jats:p>","DOI":"10.1002\/brb3.2505","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T03:40:04Z","timestamp":1645501204000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Experimental early\u2010life febrile seizures cause a sustained increase in excitatory neurotransmission in newborn dentate granule cells"],"prefix":"10.1002","volume":"12","author":[{"given":"Govert","family":"Hoogland","sequence":"first","affiliation":[{"name":"Department of Neurosurgery School for Mental Health and Neuroscience Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1398-5147","authenticated-orcid":false,"given":"Marjolein","family":"Raijmakers","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery School for Mental Health and Neuroscience Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Neurophysiology Lab Biomedical Research Institute BIOMED Hasselt University  Hasselt Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"Clynen","sequence":"additional","affiliation":[{"name":"Neurophysiology Lab Biomedical Research Institute BIOMED Hasselt University  Hasselt Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert","family":"Br\u00f4ne","sequence":"additional","affiliation":[{"name":"Neurophysiology Lab Biomedical Research Institute BIOMED Hasselt University  Hasselt 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