{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:54:16Z","timestamp":1772168056022,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transient ischemic attack (TIA) is a major risk factor for the occurrence of cerebral infarction (CI). This study aimed to evaluate the predictive value of the synthetic role of miR\u2010200b\u20103p, ABCD<jats:sup>2<\/jats:sup> score, and carotid ultrasound for CI onset in patients with TIA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Expression of miR\u2010200b\u20103p was detected by reverse transcription quantitative PCR and carotid stenosis degree was evaluated using carotid ultrasound examination. Association of miR\u2010200b\u20103p with ABCD<jats:sup>2<\/jats:sup> scores and carotid stenosis degree was assessed using <jats:italic>t<\/jats:italic>\u2010test and chi\u2010square test. Logistic regression analysis was used to judge the ability of miR\u2010200b\u20103p, ABCD<jats:sup>2<\/jats:sup> score, and carotid ultrasound to predict the occurrence of CI. Receiver operating characteristic curve was used to analyze the diagnostic value of miR\u2010200b\u20103p and the accuracy of miR\u2010200b\u20103p, ABCD<jats:sup>2<\/jats:sup> score, and carotid ultrasound in predicting CI development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Expression of serum miR\u2010200b\u20103p was significantly increased in TIA patients compared with healthy controls, and had diagnostic value in TIA patients. Serum miR\u2010200b\u20103p was significantly associated with dyslipidemia, ABCD<jats:sup>2<\/jats:sup> score, and carotid stenosis degree in TIA patients. ABCD<jats:sup>2<\/jats:sup> score, carotid stenosis degree, and serum miR\u2010200b\u20103p were independently associated with CI onset, and the synthetic role of these three indicators had the best accuracy in the prediction of CI onset in TIA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum miR\u2010200b\u20103p expression was increased in TIA patients with considerable diagnostic value to screen TIA cases from healthy controls. Moreover, we speculated that the combination of miR\u2010200b\u20103p, ABCD<jats:sup>2<\/jats:sup> score, and carotid stenosis degree by ultrasound may propose as an efficient predictive strategy for the prediction of CI in TIA patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.2518","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T08:38:24Z","timestamp":1646815104000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Synthetic role of miR\u2010200b\u20103p, ABCD<sup>2<\/sup> score, and carotid ultrasound in the prediction of cerebral infarction in patients with transient ischemic attack"],"prefix":"10.1002","volume":"12","author":[{"given":"Jiwei","family":"Zheng","sequence":"first","affiliation":[{"name":"Ultrasound Department Huantai People's Hospital  Zibo Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhirong","family":"Wang","sequence":"additional","affiliation":[{"name":"Ultrasound Department Huantai People's Hospital  Zibo Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Ultrasound Department Huantai People's Hospital  Zibo Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Neurology Department Huantai People's Hospital  Zibo Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4854-1696","authenticated-orcid":false,"given":"Xiaoguang","family":"Huo","sequence":"additional","affiliation":[{"name":"Ultrasound Department Zibo Central Hospital  Zibo Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10059\u2010011\u20101042\u20102"},{"key":"e_1_2_10_3_1","first-page":"82","article-title":"Diagnosis and management of transient ischemic attack","volume":"23","author":"Coutts S. 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