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The alterations of superficial white matter (<jats:styled-content style=\"fixed-case\">SWM<\/jats:styled-content>) in Alzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) are of special interest, since they follow the<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010specific pattern characterized by the strongest neurodegeneration of the medial temporal lobe and association cortices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, we present an<jats:styled-content style=\"fixed-case\">SWM<\/jats:styled-content>network analysis in comparison with<jats:styled-content style=\"fixed-case\">SWM<\/jats:styled-content>topography based on the myelin content quantified with magnetization transfer ratio (<jats:styled-content style=\"fixed-case\">MTR<\/jats:styled-content>) for 39 areas in each hemisphere in 15<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>patients and 15 controls. The networks are represented by graphs, in which nodes correspond to the areas, and edges denote statistical associations between them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In both groups, the networks were characterized by asymmetrically distributed edges (predominantly in the left hemisphere). The<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010related differences were also leftward. The edges lost due to<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>tended to connect nodes in the temporal lobe to other lobes or nodes within or between the latter lobes. The newly gained edges were mostly confined to the temporal and paralimbic regions, which manifest demyelination of<jats:styled-content style=\"fixed-case\">SWM<\/jats:styled-content>already in mild<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This pattern suggests that the<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>pathological process coordinates<jats:styled-content style=\"fixed-case\">SWM<\/jats:styled-content>demyelination in the temporal and paralimbic regions, but not elsewhere. A comparison of the<jats:styled-content style=\"fixed-case\">MTR<\/jats:styled-content>maps with<jats:styled-content style=\"fixed-case\">MTR<\/jats:styled-content>\u2010based networks shows that although, in general, the changes in network architecture in<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>recapitulate the topography of (de)myelination, some aspects of structural covariance (including the interhemispheric asymmetry of networks) have no immediate reflection in the myelination pattern.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.252","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T03:47:00Z","timestamp":1406605620000},"page":"721-737","source":"Crossref","is-referenced-by-count":33,"title":["Structural covariance of superficial white matter in mild Alzheimer's disease compared to normal aging"],"prefix":"10.1002","volume":"4","author":[{"given":"Cristian","family":"Carmeli","sequence":"first","affiliation":[{"name":"LREN Department of Clinical Neuroscience Centre Hospitalier Universitaire Vaudois (CHUV) University of Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Fornari","sequence":"additional","affiliation":[{"name":"Department of Radiology Centre Hospitalier Universitaire Vaudois (CHUV) University of Lausanne Lausanne Switzerland"},{"name":"CIBM (Centre d'Imag\u00e9rie Biom\u00e9dicale) CHUV Unit Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Jalili","sequence":"additional","affiliation":[{"name":"Department of Computer Engineering Sharif University of Technology Tehran Iran"},{"name":"School of Electrical and Computer Engineering RMIT University Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Meuli","sequence":"additional","affiliation":[{"name":"Department of Radiology Centre Hospitalier Universitaire Vaudois (CHUV) University of Lausanne Lausanne Switzerland"},{"name":"CIBM (Centre d'Imag\u00e9rie Biom\u00e9dicale) CHUV Unit Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G.","family":"Knyazeva","sequence":"additional","affiliation":[{"name":"LREN Department of Clinical Neuroscience Centre Hospitalier Universitaire Vaudois (CHUV) University of Lausanne Lausanne Switzerland"},{"name":"Department of Radiology Centre Hospitalier Universitaire Vaudois (CHUV) University of Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0030017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10101284"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3465"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3554-12.2013"},{"key":"e_1_2_9_6_1","first-page":"977","article-title":"Age\u2010related, regional, hemispheric, and medial\u2010lateral differences in myelin integrity in vivo in the normal adult brain","volume":"25","author":"Armstrong C. 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