{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:54:04Z","timestamp":1789462444468,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The profile of cognitive impairment associated with the late stages of Parkinson's disease (LSPD) is rarely reported. Its characterization is necessary to better understand the cognitive changes that occur as the disease progresses and to better contribute to its management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study, we characterized the cognitive profile of LSPD patients using the comprehensive assessment methodology proposed by the International Parkinson and Movement Disorders Society Task Force. The association of clinical and demographic variables with dementia diagnosis was also investigated using binary logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010four LSPD patients were included (age 75.4\u00a0\u00b1\u00a06.9; disease duration 16.9\u00a0\u00b1\u00a07.5). Fifty\u2010four (64.3%) were classified as demented and presented a global impairment cognitive profile. In the nondemented group (<jats:italic>N<\/jats:italic>\u00a0=\u00a030), 25 (83.3%) LSPD patients met the diagnostic criteria for mild cognitive impairment, mostly with multiple domain impairment (96.0%) and a heterogeneous profile. Memory was the most frequent and severely impaired cognitive domain in both groups. Disease disability, orientation, complex order comprehension, verbal learning, and visuoconstructive abilities were significantly associated with dementia diagnosis (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cognitive impairment in multiple domains was common in LSPD patients. The most frequent and prominent deficits were in the memory domain, with a strong interference from attention impairment. Disease disability, orientation, complex order comprehension, verbal learning, and visuoconstructive abilities proved to be important determinants for dementia diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.2537","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T11:59:48Z","timestamp":1646654388000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Profile of cognitive impairment in late\u2010stage Parkinson's disease"],"prefix":"10.1002","volume":"12","author":[{"given":"Catarina","family":"Severiano e Sousa","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Pharmacology and Therapeutics Faculdade de Medicina Universidade de Lisboa  Lisboa Portugal"},{"name":"Faculdade de Medicina Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes Universidade de Lisboa  Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Fabbri","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes Universidade de Lisboa  Lisboa Portugal"},{"name":"Department of Neurosciences Clinical investigation Center CIC 1436, Parkinson Toulouse Expert Center, NS\u2010Park\/FCRIN Network and NeuroToul COEN Center Toulouse University Hospital INSERM University of Toulouse 3  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Godinho","sequence":"additional","affiliation":[{"name":"Grupo de Patologia M\u00e9dica Nutri\u00e7\u00e3o e Exerc\u00edcio Cl\u00ednico (PaMNEC) do Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM) Escola Superior de Sa\u00fade Egas Moniz  Almada Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Moiron Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Beatriz \u00c2ngelo  Loures Portugal"},{"name":"Campus Neurol\u00f3gico  Torres Vedras Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Chendo","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Universit\u00e1ria de Psiquiatria Faculdade de Medicina Universidade de Lisboa  Lisbon Portugal"},{"name":"Psychiatry Department Department of Neurosciences Hospital de Santa Maria  Lisbon Portugal"},{"name":"Campus Neurol\u00f3gico  Torres Vedras Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Coelho","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes Universidade de Lisboa  Lisboa Portugal"},{"name":"Neurology Service Department of Neurosciences Hospital Santa Maria  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Pav\u00e3o Martins","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes Universidade de Lisboa  Lisboa Portugal"},{"name":"Laborat\u00f3rio de Estudos de Linguagem Faculdade de Medicina Universidade de Lisboa  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3950-5113","authenticated-orcid":false,"given":"Joaquim J.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pharmacology and Therapeutics Faculdade de Medicina Universidade de Lisboa  Lisboa Portugal"},{"name":"Faculdade de Medicina Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes Universidade de Lisboa  Lisboa Portugal"},{"name":"Campus Neurol\u00f3gico  Torres Vedras Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.4.419"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. (2014). Diagnostic and statistical manual of mental disorders DSM\u20105 (5th edn.)Arlington VA:American Psychiatric Association.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_8_4_1","volume-title":"Multilingual aphasia examination","author":"Benton A. L.","year":"1989"},{"key":"e_1_2_8_5_1","volume-title":"Contributions to neuropsychological assessment","author":"Benton A. L.","year":"1994"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702\u2010010\u20100370\u20102"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000158422.41380.82"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028\u20103932(94)90135\u2010x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/act001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acs115"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/23279095.2014.927767"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.126"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12567"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.38.5.680"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.44.12.2308"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21844"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(07)70178\u20103"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/pl00007725"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.057984"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.48.6.517"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20103956(75)90026\u20106"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000109885"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20213"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22340"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20216"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_8_27_1","volume-title":"The Boston naming test","author":"Kaplan E. F.","year":"1983"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(10)70212\u2010X"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq059"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245167"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0028\u20103932(97)00017\u20101"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2008.08.020"},{"key":"e_1_2_8_33_1","volume-title":"Neuropsychologial assessment","author":"Lezak M. D.","year":"2012"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410190404"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010008\u20100024\u20106"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24893"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/13854046.2012.748094"},{"issue":"9","key":"e_1_2_8_38_1","first-page":"10","article-title":"Novos valores normativos do Mini\u2010Mental State Examination","volume":"2","author":"Morgado J.","year":"2009","journal-title":"Sinapse"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(00)03589\u20103"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617707071160"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028\u20103932(93)90135\u2010m"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00867426"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acp039"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531\u2010020\u201000121\u20102"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610292001248"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.232678"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1958.8.3.271"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/111.3.695"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn054"},{"key":"e_1_2_8_50_1","volume-title":"Rey auditory and verbal learning test: A handbook","author":"Schmidt M.","year":"1996"},{"key":"e_1_2_8_51_1","unstructured":"Schwab R. S. &England A. C.(1969).Projection technique for evaluating surgery in Parkinson's disease. In:F.J.Gillingham&M.C.Donaldson(Eds.)Third Symposium on Parkinson's Disease Edinburgh Livingstone pp. 152\u2013157."},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.1989.tb02233.x"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065\u2010008\u20109055\u20100"},{"key":"e_1_2_8_54_1","volume-title":"Wechsler Memory Scale","author":"Wechsler D.","year":"1997"},{"key":"e_1_2_8_55_1","volume-title":"Wechsler Adult Intelligence Scale (WAIS\u20103R)","author":"Wechsler D.","year":"1997"},{"key":"e_1_2_8_56_1","volume-title":"Escala de Intelig\u00eancia de Wechsler para Adultos III","author":"Wechsler D.","year":"2008"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm111"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.2537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.2537","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.2537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T13:11:05Z","timestamp":1693228265000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.2537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,7]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1002\/brb3.2537"],"URL":"https:\/\/doi.org\/10.1002\/brb3.2537","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,7]]},"assertion":[{"value":"2021-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2537"}}