{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T08:03:00Z","timestamp":1770019380245,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T00:00:00Z","timestamp":1647734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001441"],"award-info":[{"award-number":["82001441"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Tourette syndrome (TS) is a childhood neurodevelopmental disorder caused by various genetic and environmental factors and presents with apparent genetic heterogeneity. As <jats:italic>ASH1L<\/jats:italic> potentially contributes to neurodevelopmental diseases, especially in TS, we aim to investigate the susceptibility of <jats:italic>ASH1L<\/jats:italic> on TS in the Chinese Han population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three tag single nucleotide polymorphisms (SNPs) (rs5005770, rs12734374, and rs35615695) in <jats:italic>ASH1L<\/jats:italic> were screened in 271 TS nuclear family trios and 337 healthy subjects by the TaqMan assays real time. A case\u2013control study combined with family\u2010based analysis was applied to study the genetic susceptibility of common variants of <jats:italic>ASH1L<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results revealed a significant over\u2010transmission of rs35615695 and rs5005770 (for rs35615695, transmission disequilibrium test, <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a057.375, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.000, HHRR, <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a04.807, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.028; for rs5005770, HRR, <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a04.116, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.042, HHRR, <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a08.223, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004) in family\u2010based study. Furthermore, rs5005770 and rs35615695 still remained significant after Bonferroni correction (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.017). However, the two SNPs (rs5005770 and rs35615695) were found not to be associated with TS in case\u2013control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggests that <jats:italic>ASH1L<\/jats:italic> may contribute to TS susceptibility in the Han Chinese population and involved in TS development as a risk factor.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.2539","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T05:28:34Z","timestamp":1647840514000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>ASH1L<\/i> may contribute to the risk of Tourette syndrome: Combination of family\u2010based analysis and case\u2013control study"],"prefix":"10.1002","volume":"12","author":[{"given":"Wenmiao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medical Genetics The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3108-4641","authenticated-orcid":false,"given":"Lulu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Linyi People's Hospital The Eleventh Clinical Medical College of Qingdao University  Linyi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jicheng","family":"Dong","sequence":"additional","affiliation":[{"name":"Qingdao Mental Health Center  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiguo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengyuan","family":"Che","sequence":"additional","affiliation":[{"name":"Department of Neurology Linyi People's Hospital The Eleventh Clinical Medical College of Qingdao University  Linyi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueping","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.2656"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/ben\u2010120274"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000327890.02893.61"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010010\u20105754\u20106"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0012162200000839"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.00993\u201007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010019\u20100560\u20108"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1087054713518822"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/ndt.S229420"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.08.041"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.13.7284"},{"issue":"1","key":"e_1_2_8_13_1","first-page":"154","article-title":"A family study of Gilles de la Tourette syndrome","volume":"48","author":"Pauls D. 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