{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:37:38Z","timestamp":1785285458525,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To report side effect frequency and severity in patients with major depressive disorder (MDD) receiving escitalopram and aripiprazole adjunctive therapy and to examine whether pretreatment anxious depression is associated with the number and presence of specific side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>188 of the 211 trial participants provided information on side effects during treatment with escitalopram (10\u201320\u00a0mg) for 8\u00a0weeks, and nonresponders received further augmentation on aripiprazole (2\u201310\u00a0mg) adjunctive therapy for another 8\u00a0weeks, whereas responders remained on escitalopram. Participants completed the Toronto Side Effects Scale at weeks 2, 4, 10, and 12. Covariate\u2010adjusted negative binomial regression and Wilcoxon tests examined the association between anxious depression (GAD\u20107\u00a0\u2265\u00a010) and number of side effects. Covariate\u2010adjusted logistic regression and chi\u2010square tests explored the association between anxious depression and specific side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      For both therapies, the most frequent side effects were also the most severe. They mostly related to the central nervous system (CNS) (i.e., drowsiness and nervousness). Between baseline and week 2, the number of side effects participants experienced (incidence rate ratio [IRR]\u00a0=\u00a01.38,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.010) or had trouble with (IRR\u00a0=\u00a01.34,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.026) was significantly higher among those with anxious depression for escitalopram but not adjunctive aripiprazole. Further, odds of experiencing and having trouble with nervousness and agitation were also significantly higher in anxious depression for escitalopram only (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients on escitalopram and aripiprazole adjunctive therapy may experience and have trouble with CNS side effects. Pretreatment anxious depression may predispose escitalopram recipients with MDD to developing side effects, especially those related to anxiety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2555","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T10:09:57Z","timestamp":1648202997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pretreatment anxious depression as a predictor of side effect frequency and severity in escitalopram and aripiprazole adjunctive therapy"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5479-8914","authenticated-orcid":false,"given":"Caroline W.","family":"Espinola","sequence":"first","affiliation":[{"name":"Interventional Psychiatry Program St. Michael's Hospital  Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelee","family":"Khoo","sequence":"additional","affiliation":[{"name":"Interventional Psychiatry Program St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roohie","family":"Parmar","sequence":"additional","affiliation":[{"name":"Interventional Psychiatry Program St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya","family":"Demchenko","sequence":"additional","affiliation":[{"name":"Interventional Psychiatry Program St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8267-943X","authenticated-orcid":false,"given":"Benicio N.","family":"Frey","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioural Neurosciences McMaster University  Hamilton Ontario Canada"},{"name":"Mood Disorders Program and Women's Health Concerns Clinic St. Joseph's Healthcare  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roumen V.","family":"Milev","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Psychology Queen's University  Providence Care Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun V.","family":"Ravindran","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"},{"name":"Institute of Medical Science University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar V.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Ho","sequence":"additional","affiliation":[{"name":"Interventional Psychiatry Program St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Rotzinger","sequence":"additional","affiliation":[{"name":"Interventional Psychiatry Program St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Lou","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond W.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidney H.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Interventional Psychiatry Program St. Michael's Hospital  Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"},{"name":"Institute of Medical Science University of Toronto  Toronto Ontario Canada"},{"name":"Li Ka Shing Knowledge Institute St. Michael's Hospital &amp; 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