{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T21:34:29Z","timestamp":1787780069768,"version":"build-2784847793"},"reference-count":66,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Essential tremor (ET) as a neurological disorder is accompanied by cognitive and motor disturbances. Despite the high incidence of ET, the drug treatment of ET remains unsatisfactory. Recently, abscisic acid (ABA) has been reported to have positive neurophysiological effects in mammals. Here, the effects of ABA on harmaline\u2010induced motor and cognitive impairments were investigated in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male Wistar rats weighing 120\u2013140\u00a0g were divided into control, harmaline (30\u00a0mg\/kg, ip), ABA vehicle (DMSO+normal saline), and ABA (10 \u03bcg\/rat, icv, 30\u00a0min before harmaline injection) groups. Exploratory, balance and motor performance, anxiety, and cognitive function were assessed using footprint, open field, wire grip, rotarod, and shuttle box tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results indicated that ABA (10 \u03bcg\/rat) can improve harmaline\u2010induced tremor in rats. The administration of ABA significantly increased time spent on wire grip and rotarod. In addition, ABA had a promising effect against the cognitive impairments induced by harmaline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Taken together, ABA has positive effects on locomotor and cognitive impairments induced by tremor. However, further studies are required to determine the exact mechanisms of ABA on the ET.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2564","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T03:54:42Z","timestamp":1649130882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Phytohormone abscisic acid elicits positive effects on harmaline\u2010induced cognitive and motor disturbances in a rat model of essential tremor"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2082-5849","authenticated-orcid":false,"given":"Mohammad","family":"Shabani","sequence":"first","affiliation":[{"name":"Neuroscience Research Center, Neuropharmacology Institute Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5428-4446","authenticated-orcid":false,"given":"Reyhaneh","family":"Naderi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Neuropharmacology Institute Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2016.06.013"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13581"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2018.11.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304\u20103940(02)00042\u20103"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010015\u20100367\u20105"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.160077"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986710790226110"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:NEUR.0000029648.81071.20"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11\u2010190140"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M802603200"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609379104"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.10.054"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26490"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010arplant\u2010042809\u2010112122"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22755"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20108993(96)01148\u20101"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014\u20102999(95)00795\u20104"},{"key":"e_1_2_8_19_1","first-page":"11","article-title":"Abscisic acid synthesis and response","author":"Finkelstein R.","year":"2013","journal-title":"The Arabidopsis Book\/American Society of Plant Biologists"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.08.059"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2010.06.011"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2007.02.010"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2006.07.008"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2009.10.003"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.5334\/tohm.108"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009020914358"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelekin.2011.01.002"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.756429"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395\u2010009\u20100071\u2010x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.05.015"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285613489591"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2190\/FRYK\u2010TMGA\u2010AULW\u2010BM5G"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2019.1634067"},{"key":"e_1_2_8_34_1","article-title":"Abscisic acid interplays with PPAR\u03b3 receptors and ameliorates diabetes\u2010induced cognitive deficits in rats","author":"Kooshki R.","year":"2020","journal-title":"Avicenna Journal of Phytomedicine"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20108993(71)90174\u20100"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.4.1155"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.06.042"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(05)00991\u20109"},{"key":"e_1_2_8_39_1","first-page":"3","article-title":"The effect of induced differentiation of abscisic acid on human HCC cell line SMMC\u20107721","author":"Ma Q.","year":"2006","journal-title":"Journal of Kunming Medical College"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15\u2010277731"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11\u2010187351"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnz017"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jht.2018.05.001"},{"key":"e_1_2_8_44_1","first-page":"1","article-title":"Abscisic acid and antioxidant defense in plant cells","volume":"46","author":"Ming\u2010Yi J.","year":"2004","journal-title":"Journal of Integrative Plant Biology"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-4027-7_3"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.05.013"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.09.089"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2014.02.054"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471\u20104159.2000.0741335.x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2009.06107.x"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041\u2010015\u20100093\u20102"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.05.031"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953\u2010816X.2004.03324.x"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.105.2.619"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2014.11.053"},{"key":"e_1_2_8_56_1","first-page":"18","article-title":"Antidepressant effects of abscisic acid mediated by the downregulation of corticotrophin\u2010releasing hormone gene expression in rats","author":"Qi C.\u2010C.","year":"2015","journal-title":"International Journal of Neuropsychopharmacology"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2018.2062"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233714525497"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010018\u20101091\u2010z"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-016-0137-3"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2010.11.105"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2008\u20100488"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479\u20105876\u20106\u201068"},{"key":"e_1_2_8_64_1","first-page":"121","article-title":"Effect of Acute administration of Cisplatin on memory, motor learning, balance and explorative behaviours in rats","volume":"16","author":"Shojaei A.","year":"2012","journal-title":"Physiology and Pharmacology"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2018.1431093"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.01.078"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.12.061"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.2564","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.2564","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.2564","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T09:19:29Z","timestamp":1693214369000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.2564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,5]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/brb3.2564"],"URL":"https:\/\/doi.org\/10.1002\/brb3.2564","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.2564\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2564\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2564\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2564\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2564\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2564\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2564\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2564\/v2\/response1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,5]]},"assertion":[{"value":"2021-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2564"}}