{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:31:47Z","timestamp":1786977107412,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intermittent theta burst stimulation (iTBS) is known to improve cognitive impairment caused by Alzheimer's disease and Parkinson's disease, but studies are lacking with respect to the efficacy of iTBS on poststroke cognitive impairment (PSCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was conducted to investigate the effect of left dorsolateral prefrontal cortex (DLPFC) iTBS on improving cognitive function\u00a0in stroke patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010eight patients with PSCI are randomly divided into iTBS (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a028) and sham stimulation groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a030). Both groups receive routine cognitive\u2010related rehabilitation. The iTBS group is treated with iTBS intervention of the left DLPFC, and the sham stimulation group is treated with the same parameters at the same site for 2 weeks. Outcome measures are assessed at baseline (T0) and immediately after the last intervention (T1) by mini\u2010mental state examination (MMSE), Oxford cognitive screen, and event\u2010related potential P300.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There are no differences in baseline clinical characteristics between the two groups. After intervention, the MMSE scores and P300 amplitude increase significantly for both groups, and the P300 incubation period reduces significantly. The change value of the iTBS group is significantly higher than that of sham stimulation group (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a0.05). Compared with the sham stimulation group, the iTBS group has more significant changes in semantic comprehension and executive function (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>iTBS can effectively and safely improve overall cognitive impairment in stroke patients, including semantic understanding and executive function, and it also has a positive impact on memory function. Future randomized controlled studies with large samples and long\u2010term follow\u2010up should be conducted to further validate the results of the present study<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2569","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T03:51:13Z","timestamp":1651204273000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Improvement of poststroke cognitive impairment by intermittent theta bursts: A double\u2010blind randomized controlled trial"],"prefix":"10.1002","volume":"12","author":[{"given":"Wen","family":"Li","sequence":"first","affiliation":[{"name":"Rehabilitation Medicine Department Affiliated Hospital of North Sichuan Medical College  Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wen","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Department Affiliated Hospital of North Sichuan Medical College  Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Han","family":"Xie","sequence":"additional","affiliation":[{"name":"University of South China  Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An\u2010Li","family":"Hu","sequence":"additional","affiliation":[{"name":"Hubei University Of Economics  WuHan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wu","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Department Affiliated Hospital of North Sichuan Medical College  Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2059-8719","authenticated-orcid":false,"given":"Yin\u2010Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Department Affiliated Hospital of North Sichuan Medical College  Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2196\/resprot.9431"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.01.037"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.3469"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afs116"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.08.020"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2011.04.006"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2018.10.009"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2020.05.013"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/02699052.2014.934921"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-017-0459-3"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5136"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00177"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04786-8"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3182299496"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ensci.2018.04.004"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhv193"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227820"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.119"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.584374"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2021.01.012"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00977"},{"issue":"32","key":"e_1_2_10_23_1","first-page":"p31","article-title":"Logistic regression combined with ROC curve to explore the value of event\u2010related potential P300 in patients with post\u2010stroke cognitive dys\u2010function","volume":"38","author":"Lin Z. 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