{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:01:54Z","timestamp":1772118114972,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Spectral\u2010domain optical coherence tomography (OCT) may detect retinal changes as a biomarker in neurodegenerative diseases like manifest Huntington's disease (HD). We investigate macular retinal layer thicknesses in a premanifest HD (pre\u2010HD) cohort and healthy controls (HC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pre\u2010HD mutation carriers underwent standardized ratings and a preset macular OCT scan. Thickness values were determined for each sector of all macular retinal layers, the mean of all sectors and the mean of the inner ring (IR, 3\u00a0mm) after segmentation (Heyex segmentation batch). HC were retrospectively included from an existing database. The IR thickness of the ganglion cell layer (GCL), retinal nerve fiber layer (RNFL), GCL + inner plexiform layer (GCIPL), and total retina were included in the exploratory correlation analyses with paraclinical ratings and compared to HC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The analyses comprised\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a024 pre\u2010HD participants (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a010 male,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a014 female) and\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\u00a038 HC (\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\u00a014 male,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a024 female). Retinal layer parameters did not correlate with paraclinical ratings. Expected correlations between established HD biomarkers were robust. The IR thicknesses of the GCL, GCIPL, and total retina did not differ between pre\u2010HD and HC. The IR thickness of the RNFL was significantly higher in pre\u2010HD participants (pre\u2010HD: 23.22\u00a0\u03bcm (standard deviation 2.91), HC: 21.26\u00a0\u03bcm (1.90),\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a0.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>In this cross\u2010sectional cohort of genetically determined pre\u2010HD participants, neurodegenerative features were not detected with retinal layer segmentation. Since our pre\u2010HD collective was more than 16 years before disease onset, OCT may not be sensitive enough to detect early changes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2592","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T10:58:39Z","timestamp":1651748319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["No optical coherence tomography changes in premanifest Huntington's disease mutation carriers far from disease onset"],"prefix":"10.1002","volume":"12","author":[{"given":"Rahel Dominique","family":"Schmid","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Inselspital, Bern University Hospital and University of Bern  Bern Switzerland"},{"name":"Department of Neurology Inselspital, Bern University Hospital and University of Bern  Bern 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Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Neurology St. Josef\u2010Hospital Ruhr\u2010University Bochum Huntington Center NRW  Bochum Germany"},{"name":"Department of Neuropsychiatry Huntington Center South kbo\u2010Isar\u2010Amper\u2010Klinikum, Taufkirchen (Vils)  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Lukas","sequence":"additional","affiliation":[{"name":"Institute of Neuroradiology St. Josef\u2010Hospital Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Saft","sequence":"additional","affiliation":[{"name":"Department of Neurology St. Josef\u2010Hospital Ruhr\u2010University Bochum Huntington Center NRW  Bochum 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