{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:01:29Z","timestamp":1781103689977,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Bidirectional effects between cognition and pain have been extensively reported. Although brain regions involved in cognitive and pain processing seem to partly overlap, it is unknown what specific brain regions are involved in the interaction between pain and cognition. Furthermore, the role of gonadal hormones on these interacting effects has not been examined. This study investigated brain activation patterns of the interaction between pain and cognition over different phases of the naturally occurring menstrual cycle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifteen healthy normally cycling females were examined over the course of 4 different cycle phases. Sensory stimulation was applied using electrical pulses and cognitive performance was assessed using the Multi\u2010Source Interference Task. Brain imaging consisted of functional magnetic resonance imaging using a repeated measures ANOVA group analysis approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sensory stimulation was found to interact with task performance in the left precuneus, left posterior cingulate cortex and right inferior parietal lobule. No effects of cycle phase were observed to interact with main effects of stimulation, task or interaction effects between task performance and sensory stimulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Potential neural correlates of shared resources between pain and cognition were demonstrated providing further insights into the potential mechanisms behind cognitive performance difficulties in pain patients and opening avenues for new treatment options including targeting specific cognitive factors in pain treatment such as cognitive interference.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2593","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T04:46:44Z","timestamp":1651726004000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Brain responses to painful electrical stimuli and cognitive tasks interact in the precuneus, posterior cingulate cortex, and inferior parietal cortex and do not vary across the menstrual cycle"],"prefix":"10.1002","volume":"12","author":[{"given":"Dieuwke S.","family":"Veldhuijzen","sequence":"first","affiliation":[{"name":"Institute of Psychology Health, Medical and Neuropsychology Unit Leiden University  Leiden the Netherlands"},{"name":"Leiden Institute for Brain and Cognition  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Meeker","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Johns Hopkins University  Baltimore Maryland"},{"name":"Department of Neural and Pain Sciences University of Maryland School of Dentistry  Baltimore Maryland"},{"name":"Center to Advance Chronic Pain Research University of Maryland Baltimore  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Neural and Pain Sciences University of Maryland School of Dentistry  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Keaser","sequence":"additional","affiliation":[{"name":"Department of Neural and Pain Sciences University of Maryland School of Dentistry  Baltimore Maryland"},{"name":"Center to Advance Chronic Pain Research University of Maryland Baltimore  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rao P.","family":"Gullapalli","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Nuclear Imaging University of Maryland School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel D.","family":"Greenspan","sequence":"additional","affiliation":[{"name":"Department of Neural and Pain Sciences University of Maryland School of Dentistry  Baltimore Maryland"},{"name":"Center to Advance Chronic Pain Research University of Maryland Baltimore  Baltimore 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