{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:23:37Z","timestamp":1764937417920,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The study aimed to analyze the relationship between expression levels of chemerin, oxidized low density lipoprotein (ox\u2010LDL), matrix metalloproteinase 9 (MMP\u20109) and pregnancy associated plasma protein A (PAPP\u2010A) in ischemic cerebrovascular disease (ICVD) patients and the relationship between the mentioned indicators and the degree of neurological impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 2020 to February 2021, a total of 328 cases of ICVD patients were admitted to our hospital, and 240 cases of healthy people (control group) were prospectively recruited into this study. The 328 patients were divided into 2 ischemic subtypes, with 233 cases as acute cerebral infarction (ACI) and 95 cases as transient ischemic attack (TIA). Laboratory tests were compared among the groups. Spearman rank correlation was used to analyze the correlation between chemerin, ox\u2010LDL, MMP\u20109, PAPP\u2010A levels and neurological deficit. Unconditional logisitic regression was used to analyze the risk factors for neurological deficits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The high density lipoprotein cholesterol (HDL\u2010C), fasting plasma glucose (FPG), chemerin, ox\u2010LDL, MMP\u20109, and PPAP\u2010A levels in the ACI group were significantly higher than those in the TIA group and control group (<jats:italic>p<\/jats:italic> &lt; 0.05, respectively), while the levels of the mentioned indicators in the TIA group were significantly higher than those in control group (<jats:italic>p<\/jats:italic> &lt; 0.05, respectively). The levels of the given indicators decreased successively in the severe, moderate, and mild neurological deficits population and control group, with statistical difference. Spearman rank correlation analysis showed that chemerin, ox\u2010LDL, MMP\u20109, and PPAP\u2010A levels were positively correlated with the degree of neurological deficit in ICVD patients. Unconditional logistic regression analysis showed that chemerin, ox\u2010LDL, MMP\u20109, and PPAP\u2010A were the independent risk factors for neurological deficit in patients with ICVD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LDL\u2010C, FPG, chemerin, ox\u2010LDL, MMP\u20109, and PPAP\u2010A were highly expressed in ACI and neurological deficit patients. Chemerin, ox\u2010LDL, MMP\u20109, and PPAP\u2010A may be the independent risk factors for neurological deficit in patients with ICVD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.2613","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T06:47:51Z","timestamp":1653634071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Analysis of the expression levels of chemerin, ox\u2010LDL, MMP\u20109, and PAPP\u2010A in ICVD patients and their relationship with the severity of neurological impairment"],"prefix":"10.1002","volume":"12","author":[{"given":"Jianpu","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Neurology Cangzhou Central Hospital  Cangzhou Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Cangzhou Central Hospital  Cangzhou Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Cangzhou Central Hospital  Cangzhou Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurology Cangzhou Central Hospital  Cangzhou Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruixue","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Neurology Cangzhou Central Hospital  Cangzhou Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology Cangzhou Central Hospital  Cangzhou Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4489-132X","authenticated-orcid":false,"given":"Leguo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Cangzhou Central Hospital  Cangzhou Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"issue":"7","key":"e_1_2_10_2_1","first-page":"494","article-title":"Study on multi\u2010center investigation of the Chinese version of National Institutes of Health Stroke Scale","volume":"31","author":"Cai Y. 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