{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:15:33Z","timestamp":1782458133391,"version":"3.54.5"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1S10OD025025\u201001"],"award-info":[{"award-number":["1S10OD025025\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We compared neuropsychiatric symptoms between child and adolescent huntingtin gene\u2010mutation carriers and noncarriers. Given previous evidence of atypical striatal development in carriers, we also assessed the relationship between neuropsychiatric traits and striatal development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants between 6 and 18 years old were recruited from families affected by Huntington's disease and tested for the huntingtin gene expansion. Neuropsychiatric traits were assessed using the Pediatric Behavior Scale and the Behavior Rating Inventory of Executive Function. Striatal volumes were extracted from 3T neuro\u2010anatomical images. Multivariable linear regression models were conducted to evaluate the impact of group (i.e., gene nonexpanded [GNE] or gene expanded [GE]), age, and trajectory of striatal growth on neuropsychiatric symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no group differences in any behavioral measure with the exception of depression\/anxiety score, which was higher in the GNE group compared to the GE group (estimate\u00a0=\u00a04.58,\n                      <jats:italic>t<\/jats:italic>\n                      (129)\u00a0=\u00a02.52, FDR\u00a0=\u00a00.051). The growth trajectory of striatal volume predicted depression scores (estimate\u00a0=\u00a00.429, 95% CI 0.15:0.71,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0029), where a negative slope of striatal volume over time was associated with lower depression\/anxiety.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The current findings show that GE children may have lower depression\/anxiety compared to their peers. Previously, we observed a unique pattern of early striatal hypertrophy and continued decrement in volume over time among GE children and adolescents. In contrast, GNE individuals largely show striatal volume growth. These findings suggest that the lower scores of depression and anxiety seen in GE children and adolescents may be associated with differential growth of the striatum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2630","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T13:48:56Z","timestamp":1653313736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Behavioral features in child and adolescent huntingtin gene\u2010mutation carriers"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4764-0801","authenticated-orcid":false,"given":"Erin E.","family":"Reasoner","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Iowa Hospital and Clinics  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"van der Plas","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Iowa Hospital and Clinics  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5188-5521","authenticated-orcid":false,"given":"Hend M.","family":"Al\u2010Kaylani","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Iowa Hospital and Clinics  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas R.","family":"Langbehn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Iowa Hospital and Clinics  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Conrad","sequence":"additional","affiliation":[{"name":"Stead Family Children's Hospital at the University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan L.","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Iowa Hospital and Clinics  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Epping","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Iowa Hospital and Clinics  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent A.","family":"Magnotta","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Iowa Hospital and Clinics  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8810-1903","authenticated-orcid":false,"given":"Peggy C.","family":"Nopoulos","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Iowa Hospital and Clinics  Iowa City Iowa USA"},{"name":"Stead Family Children's Hospital at the University of Iowa  Iowa City 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