{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T07:06:57Z","timestamp":1785654417763,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T00:00:00Z","timestamp":1657411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ME3675\/1\u20101"],"award-info":[{"award-number":["ME3675\/1\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Despite growing evidence validating placebo effects in nausea, little is known about the underlying cortical mechanisms in women and men. Therefore, the present study examined sex differences and electroencephalography (EEG) characteristics of the placebo effect on nausea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>On 2 consecutive days, 90 healthy subjects (45 females) were exposed to a nauseating visual stimulus. Nausea was continuously rated on an 11\u2010point numeric rating scale, and 32 EEG channels were recorded. On day 2, subjects were randomly allocated to either placebo treatment or no treatment: the placebo group received sham acupuncture, whereas the control group did not receive any intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In contrast to the control group, both sexes in the placebo group showed reduced signs for anticipatory nausea in the EEG, indexed by increased frontal lobe and anterior cingulate activity. Among women, the improvement in perceived nausea in the placebo group was accompanied by decreased activation in the parietal, frontal, and temporal lobes. In contrast, the placebo\u2010related improvement of perceived nausea in men was accompanied by increased activation in the limbic and sublobar (insular) lobes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Activation of the parietal lobe in women during the placebo intervention may reflect altered afferent activity from gastric mechanoreceptors during nausea\u2010induced tachyarrhythmia, whereas in men, altered interoceptive signals in the insular cortex might play a role. Thus, the results suggest different cerebral mechanisms underlying the placebo effects in men and women, which could have implications for the treatment of nausea.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2685","type":"journal-article","created":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T12:38:45Z","timestamp":1657456725000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Central correlates of placebo effects in nausea differ between men and women"],"prefix":"10.1002","volume":"12","author":[{"given":"Anja","family":"Haile","sequence":"first","affiliation":[{"name":"Institute of Medical Psychology, Faculty of Medicine LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallissa","family":"Watts","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology, Faculty of Medicine LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Aichner","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology, Faculty of Medicine LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Stahlberg","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology, Faculty of Medicine LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology, Faculty of Medicine LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias H.","family":"Tschoep","sequence":"additional","affiliation":[{"name":"Helmholtz Diabetes Center and German Center for Diabetes Research Helmholtz Zentrum M\u00fcnchen  Neuherberg Germany"},{"name":"Division of Metabolic Diseases, Department of Medicine Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8308-6537","authenticated-orcid":false,"given":"Karin","family":"Meissner","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology, Faculty of Medicine LMU Munich  Munich Germany"},{"name":"Division of Health Promotion Coburg University of Applied Sciences &amp; 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