{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T07:19:14Z","timestamp":1781939954663,"version":"3.54.5"},"reference-count":70,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Military members and veterans are at elevated risk of treatment\u2010resistant posttraumatic stress disorder (TR\u2010PTSD) due to higher rates of exposure to potentially traumatic events during the course of duty. Knowledge of TR\u2010PTSD is limited, and specific protocols or evidence\u2010based TR\u2010PTSD therapies are lacking. Multimodal motion\u2010assisted memory desensitization and reconsolidation (3MDR) therapy is an emerging intervention for combat\u2010related TR\u2010PTSD. The purpose of this study was to preliminarily assess the effectiveness of 3MDR in addressing TR\u2010PTSD in Canadian military members and veterans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study is a longitudinal mixed\u2010methods clinical trial. English\u2010speaking military members and veterans aged 18\u201360 with TR\u2010PTSD were recruited to participate. The intervention consisted of six sessions of 3MDR therapy. Quantitative data were collected pretreatment, posttreatment, and longitudinally at 1, 3, and 6 months after completion of 3MDR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Results from the first 11 participants to complete the 3MDR protocol exhibited statistically significant improvement (surviving multiple comparison correction) in clinically administered and self\u2010reported scores for PTSD (CAPS\u20105 and PCL\u20105), moral injury (MISS\u2010M\u2010SF), depression (PHQ\u20109), anxiety (GAD\u20107), emotional regulation (DERS\u201018), and resilience (CD\u2010RS\u201025).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The preliminary and exploratory results from this clinical trial support the growing body of literature illustrating 3MDR as an effective treatment for military\u2010related TR\u2010PTSD. These results are notable given participants' previous lack of success with frontline psychotherapeutic and pharmacological interventions. Given that there are currently very limited treatment options for TR\u2010PTSD, 3MDR could prove to be a valuable treatment option for military members and veterans with TR\u2010PTSD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2694","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T14:29:32Z","timestamp":1658154572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Quantitative changes in mental health measures with 3MDR treatment for Canadian military members and veterans"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7713-4099","authenticated-orcid":false,"given":"Chelsea","family":"Jones","sequence":"first","affiliation":[{"name":"Leiden University Medical Centre Leiden University  Leiden the Netherlands"},{"name":"Alberta Health Services, Edmonton  Ottawa Canada"},{"name":"Heroes in Mind, Advocacy and Research Consortium (HiMARC), Faculty of Rehabilitation Medicine University of Alberta  Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3712-0674","authenticated-orcid":false,"given":"Lorraine","family":"Smith\u2010MacDonald","sequence":"additional","affiliation":[{"name":"Heroes in Mind, Advocacy and Research Consortium (HiMARC), Faculty of Rehabilitation Medicine University of Alberta  Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8448-3710","authenticated-orcid":false,"given":"Matthew Robert Graham","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Computing Science University of Alberta  Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3132-4676","authenticated-orcid":false,"given":"Ashley","family":"Pike","sequence":"additional","affiliation":[{"name":"Heroes in Mind, Advocacy and Research Consortium (HiMARC), Faculty of Rehabilitation Medicine University of Alberta  Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0579-4404","authenticated-orcid":false,"given":"Eric","family":"Vermetten","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre Leiden University  Leiden the Netherlands"},{"name":"ARQ National Psychotrauma Center  Diemen the Netherlands"},{"name":"Military Mental Health Service Dutch Ministry of Defence  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4167-1815","authenticated-orcid":false,"given":"Suzette","family":"Br\u00e9mault\u2010Phillips","sequence":"additional","affiliation":[{"name":"Heroes in Mind, Advocacy and Research Consortium (HiMARC), Faculty of Rehabilitation Medicine University of Alberta  Edmonton Canada"},{"name":"Department of Occupational Therapy Faculty of Rehabilitation Medicine University of Alberta  Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.paid.2011.03.025"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0170840618782294"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517\u20106161.1995.tb02031.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4324\/9780203359075"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.7.1337"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.22421"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13200"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.2490080106"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.7.821"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/10826084.2013.796990"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.22567"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2021.113712"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.10113"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003262"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpp.1866"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpp.2170"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2020.07.046"},{"key":"e_1_2_11_20_1","unstructured":"Department of Defence and Veterans Affairs. 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