{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:00:13Z","timestamp":1789664413766,"version":"4.0.1"},"reference-count":71,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016806","name":"Natural Science Foundation of Nantong City","doi-asserted-by":"publisher","award":["JC2021139"],"award-info":[{"award-number":["JC2021139"]}],"id":[{"id":"10.13039\/100016806","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873795"],"award-info":[{"award-number":["81873795"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900551"],"award-info":[{"award-number":["81900551"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The most striking feature of depression is sadness and a loss of interest in activities, which represents a\u00a0major\u00a0cause of disability globally. Therefore, it is necessary to identify novel antidepressants for clinical practice. Ginsenoside Rh2 (Rh2) is one of the major bioactive ginsenosides that can be extracted from Panax ginseng and has been demonstrated to improve both memory and learning. The purpose of this study was to provide broad insight into the mechanisms underlying depression and gain greater insights into antidepressant therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we first established an effective and feasible depression animal model of chronic unpredictable mild stress (CUMS) and behavioral testing was evaluated by the forced swim test (FST), the tail suspension test (TST) and the sucrose preference test. Following pretreatment with Rh2 (10 and 20\u00a0mg\/kg), the immobility time of mice was reduced without affecting locomotor activity in both the FST and TST. Western blotting and immunofluorescence were used to investigate the activation of the hippocampal BDNF signaling pathway and hippocampal neurogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Different concentrations of Rh2 significantly reduced depressive\u2010like symptoms in CUMS\u2010induced mice and downregulated the effects of the BDNF signaling cascade and neurogenesis in the hippocampus. Furthermore, the administration of K252a completely prevented the antidepressant\u2010like activity of Rh2 in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results indicated that Rh2 possesses the antidepression action via the positive regulation of the BDNF\u2010TrkB pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2705","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T09:44:38Z","timestamp":1658137478000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Ginsenoside Rh2 administration produces crucial antidepressant\u2010like effects in a CUMS\u2010induced mice model of depression"],"prefix":"10.1002","volume":"12","author":[{"given":"Lin\u2010Sheng","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Cardiology Affiliated Hospital 2 of Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Hui","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Pharmacy College, Nantong University  Nantong China"},{"name":"Provincial key laboratory of Inflammation and Molecular Drug Target  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Pharmacy College, Nantong University  Nantong China"},{"name":"Provincial key laboratory of Inflammation and Molecular Drug Target  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang\u2010Hong","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Pharmacy College, Nantong University  Nantong China"},{"name":"Provincial key laboratory of Inflammation and Molecular Drug Target  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Qian","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Pharmacy College, Nantong University  Nantong China"},{"name":"Provincial key laboratory of Inflammation and Molecular Drug Target  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Pharmacy College, Nantong University  Nantong China"},{"name":"Provincial key laboratory of Inflammation and Molecular Drug Target  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7967-3456","authenticated-orcid":false,"given":"Wei","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Pharmacy College, Nantong University  Nantong China"},{"name":"School of Medicine Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.12.002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.111.005108"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs20160009"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13097tx3c"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.04.024"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10874"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24050870"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010163"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1509"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207777"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.03.009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.082"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14630"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyaa067"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2018.09.001"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13002"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2021.135994"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190329122852"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010019\u20101474\u20108"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10091208"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyv010"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010014\u20103802\u20100"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.10.004"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13668"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5733"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010020\u201003121\u20100"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07455"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/515182a"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.08.031"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5103"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112627"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010016\u20100107\u20102"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.107734"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.2235\u201016.2016"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2018.03.005"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6804"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2037"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105918"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.03.026"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21031170"},{"issue":"143","key":"e_1_2_10_42_1","first-page":"127","article-title":"BDNF as a biomarker in diagnosis and evaluation of treatment for schizophrenia and depression","volume":"26","author":"Peng S.","year":"2018","journal-title":"Discovery Medicine"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010004\u20102048\u20107"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.152862"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2017.08.009"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.2.4.590"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.11.020"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.21307\/ane\u20102017\u2010031"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520936177"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2020.02.003"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.36660\/abc.20190368"},{"issue":"5","key":"e_1_2_10_52_1","first-page":"2189","article-title":"Ginsenoside Rh2 alleviates tumor\u2010associated depression in a mouse model of colorectal carcinoma","volume":"8","author":"Wang J.","year":"2016","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.07.096"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.3779\/j.issn.1009\u20103419.2020.102.30"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.5490"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2016.08.002"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyy028"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.10.008"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/650729"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7426538"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.5740\/jaoacint.17\u20100220"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1461145709990733"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567202617666200319141755"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.11.092"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.3791\/52587"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24112035"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2015.10.018"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyz032"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2017.12.024"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8860968"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010018\u20101205\u20107"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.02.031"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.2705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.2705","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.2705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T04:14:43Z","timestamp":1692677683000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.2705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,18]]},"references-count":71,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1002\/brb3.2705"],"URL":"https:\/\/doi.org\/10.1002\/brb3.2705","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.2705\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2705\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2705\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2705\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2705\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.2705\/v2\/response1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,18]]},"assertion":[{"value":"2022-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2705"}}