{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:40:54Z","timestamp":1792096854686,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Attention deficit\/hyperactivity disorder (ADHD) is a hereditary neurodevelopmental disorder characterized by working memory (WM) deficits. The\n                      <jats:italic>Mnl<\/jats:italic>\n                      I variant (rs3746544) of the synaptosomal\u2010associated protein 25 (SNAP\u201025) gene is associated with ADHD. In this study, we investigated the role and underlying mechanism of SNAP\u201025\n                      <jats:italic>Mnl<\/jats:italic>\n                      I variant in cognitive impairment and brain functions in boys with ADHD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We performed WM capacity tests using the fourth version of the Wechsler Intelligence Scale for Children (WISC\u2010IV) and regional homogeneity (ReHo) analysis for the resting\u2010state functional magnetic resonance imaging data of 56 boys with ADHD divided into two genotypic groups (TT homozygotes and G\u2010allele carriers). Next, Spearman's rank correlation analysis between the obtained ReHo values and the WM index (WMI) calculated for each participant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with G\u2010allele carrier group, there were higher ReHo values for the left medial prefrontal cortex (mPFC) and higher WM capacity in TT homozygote group. Contrary to TT homozygote group, the WM capacity was negatively correlated with the peak ReHo value for the left mPFC in G\u2010allele carrier group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These findings suggest that SNAP\u201025\n                      <jats:italic>Mnl<\/jats:italic>\n                      I variant may underlie cognitive and brain function impairments in boys with ADHD, thus suggesting its potential as a new target for ADHD treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2758","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T02:45:22Z","timestamp":1662518722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of SNAP\u201025\n                    <i>Mnl<\/i>\n                    I variant in impaired working memory and brain functions in attention deficit\/hyperactivity disorder"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9276-0127","authenticated-orcid":false,"given":"Diangang","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Radiology Shenzhen Children's Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binrang","family":"Yang","sequence":"additional","affiliation":[{"name":"Development and Behavior Specialty Shenzhen Children's Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Center Fuwai Hospital CAMS&amp;PUMC  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Radiology Shenzhen Children's Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yungen","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Radiology Shenzhen Children's Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Radiology Shenzhen Children's Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking University Shenzhen hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Radiology Shenzhen Children's Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000733"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.74"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2014.136"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001092"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb11284.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","unstructured":"Christiansen L. Beck M. M. Bilenberg N. Wienecke J. Astrup A. &Lundbye\u2010Jensen J.(2019).Effects of exercise on cognitive performance in children and adolescents with ADHD: Potential mechanisms and evidence\u2010based recommendations.Journal of Clinical Medicine 8.","DOI":"10.3390\/jcm8060841"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.11.024"},{"key":"e_1_2_7_9_1","first-page":"361","article-title":"Candidate genes involved in neural plasticity and the risk for attention\u2010deficit hyperactivity disorder: A meta\u2010analysis of 8 common variants","volume":"34","author":"Forero D. 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