{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:02:21Z","timestamp":1772118141075,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Disruption of cortical gray matter and white matter tracts are well\u2010established markers of alcohol use disorder (AUD), but less is known about whether similar differences are present in intracortical myelin (ICM, i.e., highly myelinated gray matter in deeper cortical layers). The goal of this study was to provide initial proof\u2010of\u2010concept for using an optimized structural magnetic resonance imaging (MRI) sequence to detect differences in ICM in individuals with AUD compared to control participants reporting drinking within recommended guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study used an optimized 3T MRI sequence for high intracortical contrast to examine ICM\u2010related MRI signal in 30 individuals with AUD and 33 healthy social drinkers. Surface\u2010based analytic techniques were used to quantify ICM\u2010related MRI signal in 20 bilateral a priori regions of interest based on prior cortical thickness studies, and exploratory vertex\u2010wise analyses were examined using Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      effect size.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The global distribution of ICM\u2010related signal was largely comparable between groups. Region of interest analysis indicated that AUD group exhibited greater ICM\u2010related MRI signal in precuneus, ventromedial prefrontal cortex, posterior cingulate, middle anterior cingulate, middle\/posterior insula, and dorsolateral prefrontal cortex (Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      s\u00a0=\u00a00.50\u20130.75). Four regions (right precuneus, ventromedial prefrontal cortex, posterior cingulate and left dorsolateral prefrontal cortex) remained significant (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u00a0.05) after covarying for smoking status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings provide initial evidence of ICM differences in a moderately sized sample of individuals with AUD compared to controls, although the inflation of type 1 error rate necessitates caution in drawing conclusions. Robustly establishing these differences in larger samples is necessary. The cross\u2010sectional design cannot address whether the observed differences predate AUD or are consequences of heavy alcohol consumption.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2762","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T04:01:42Z","timestamp":1663128102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intracortical myelin in individuals with alcohol use disorder: An initial proof\u2010of\u2010concept study"],"prefix":"10.1002","volume":"12","author":[{"given":"Vanessa","family":"Morris","sequence":"first","affiliation":[{"name":"Peter Boris Center for Addictions Research McMaster University  Hamilton Canada"},{"name":"Department of Psychology York University  Toronto Canada"},{"name":"Department of Psychology University of New Brunswick Saint John  Saint John 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