{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:02:21Z","timestamp":1772118141146,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871999"],"award-info":[{"award-number":["81871999"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ornithine transcarbamylase deficiency (OTCD) is a genetic metabolic disease. Its clinical manifestations are mainly central nervous system dysfunction caused by high blood ammonia. Late\u2010onset OTCD combined with central nervous system injury has a poor therapeutic response, which is one of the main factors affecting the prognosis and quality of life of patients. liver transplantation (LT) has gradually become a radical treatment for OTCD, which has achieved good results. However, there is no consensus on the timing of LT and problems of nervous system damage and repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report the development of late\u2010onset OTCD with central nervous system injury in an 11\u2010year\u2010old child who received liver transplantation at our transplant center. His first symptoms were nonprojectile vomiting, followed by irritability and disturbance of consciousness, after which the disease progressed rapidly and finally resulted in a coma. After liver transplantation, the child's consciousness returned to normal, muscle strength of the limbs gradually recovered from grade 0 to grade 4, and muscle tone gradually recovered from grade 4 to grade 1, suggesting that the motor nerves had gradually recovered. However, the child is currently mentally retarded, and the language center has not yet fully recovered.At the same time, we made a literature review of OTCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For OTCD patients with central nervous system injury, liver transplantation can fundamentally solve the problem of ammonia metabolism in the liver and avoids further damage to the central nervous system caused by hyperammonemia. At the same time, children's nervous systems are in the developmental stage when neuroplasticity is greatest. If liver transplantation is performed as soon as possible, nerve repair is still possible.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2765","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T02:40:31Z","timestamp":1663728031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Liver transplantation in rare late\u2010onset ornithine transcarbamylase deficiency with central nervous system injury: A case report and review of the literature"],"prefix":"10.1002","volume":"12","author":[{"given":"Xin","family":"Jin","sequence":"first","affiliation":[{"name":"Division of Liver Surgery and Organ Transplantation Center, Shenzhen Third People's Hospital Second Affiliated Hospital of Southern University of Science and Technology, National Clinical Research Center for Infectious Disease  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinchen","family":"Zeng","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery and Organ Transplantation Center, Shenzhen Third People's Hospital Second Affiliated Hospital of Southern University of Science and Technology, National Clinical Research Center for Infectious Disease  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery and Organ Transplantation Center, Shenzhen Third People's Hospital Second Affiliated Hospital of Southern University of Science and Technology, National Clinical Research Center for Infectious Disease  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7348-4999","authenticated-orcid":false,"given":"Nan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery and Organ Transplantation Center, Shenzhen Third People's Hospital Second Affiliated Hospital of Southern University of Science and Technology, National Clinical Research Center for Infectious Disease  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3303033"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-012-1702-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1838-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0992-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2009.02.012"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600306"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-012-9546-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-015-0266-1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.500040504"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2010.02.012"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2012.27.5.556"},{"issue":"1","key":"e_1_2_7_13_1","first-page":"10","article-title":"Severe cerebral damage in ornithine transcarbamylase deficiency","volume":"7","author":"Dolman C. 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