{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:42:49Z","timestamp":1787726569859,"version":"build-2784847793"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC0901504"],"award-info":[{"award-number":["2016YFC0901504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["ZY2016203"],"award-info":[{"award-number":["ZY2016203"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multiple system atrophy (MSA) is an incurable neurodegenerative disease. We aimed to investigate the health\u2010related quality of life (HRQoL) and the determinants of HRQoL in patients with MSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The five\u2010level EuroQol five\u2010dimensional questionnaire (EQ\u20105D\u20105L) was used to evaluate patients\u2019 HRQoL. The results of HRQoL were indicated by the EQ\u20105D\u20105L index values and visual analog scale (EQ VAS) scores. Specific scales were used to measure disease severity, cognition, frontal lobe function, anxiety, depression, fatigue, and sleep disorders. The beta mixture model and the linear regression model were used to explore the determinants of HRQoL in patients with MSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 205 patients with cerebellar variants (MSA\u2010C; 53.9%) and 175 patients with parkinsonian variants (MSA\u2010P; 46.1%) were included in this cross\u2010sectional study. The mean values of the EQ\u20105D\u20105L index values and EQ VAS scores were .558 and 59.5, respectively. Problem with mobility was the problem reported by the highest proportion of patients (92.1%), followed by problems with usual activities (88.7%), self\u2010care (81.3%), anxiety\/depression (72.1%), and pain\/discomfort (53.9%). The determinants of the lower EQ\u20105D\u20105L index values in patients with MSA were greater disease severity, fatigue, Parkinson's disease\u2010related sleep problems (PD\u2010SP), depressive mood, and anxious mood. Greater disease severity, fatigue, and depressive mood were associated with lower EQ VAS scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The problem reported most frequently by Chinese individuals with MSA was mobility. In addition to the greater disease severity of MSA, fatigue, PD\u2010SP, depression, and anxiety were determinants of poor HRQoL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2774","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T02:09:23Z","timestamp":1663639763000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Health\u2010related quality of life in patients with multiple system atrophy using the EQ\u20105D\u20105L"],"prefix":"10.1002","volume":"12","author":[{"given":"Yi","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Neurology, Rare Disease Center, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatric, West China Hospital Sichuan University  Chengdu 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