{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T13:20:22Z","timestamp":1788441622126,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T00:00:00Z","timestamp":1665273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771323"],"award-info":[{"award-number":["31771323"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901128"],"award-info":[{"award-number":["81901128"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171137"],"award-info":[{"award-number":["32171137"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Under the condition of stress, the hypothalamic\u2013pituitary\u2013adrenal axis (HPA axis) is activated and causes the secretion of corticotropin\u2010releasing factor (CRF). Previous studies have demonstrated that CRF is involved in the regulation of pain and itch. Thus, it remains worthy to explore whether the desensitization of pain and itch under high\u2010intensity acute stress (such as high fear and tension) is related to the sharp increase of CRF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forced swimming was used to simulate acute stress. ELISA and pharmacological methods were conducted to observe the effects of forced swimming on acute pain or itch and the relationship between blood CRF content and itch or pain behavior. Intracerebroventricular (ICV) administration of CRF was conducted to examine the effects of CRF on acute pain or itch. Intrathecal administration of CRF receptor agonist or antagonist was conducted to examine the receptor mechanisms of the regulatory role of CRF in pain and itch.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ELISA experiment showed that the serum CRF in mice reached its peak within 5\u201310 min after acute stress (forced swimming). Behavioral data showed that the scratching behavior induced by itch agents decreased after acute swimming, while the mechanical pain threshold increased significantly. The inhibitory effect of acute stress on pain and itch is mediated by CRF receptor2 (CRFR2). Then, ICV injection of CRF was used to simulate the massive release of CRF under acute stress, and we observed that the scratching behavior induced by histamine or chloroquine was significantly inhibited after ICV injection of CRF. The above effects of CRF are mainly mediated by CRFR2. These results suggest that 5\u201310\u00a0min after acute stress, a large amount of CRF is released into the blood from the hypothalamus, which significantly inhibits acute pain and itch by acting on CRFR2. ICV injection of CRF can replicate the antipruritus effects of acute stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present study investigated the mechanism of acute stress\u2010induced analgesia and antipruritus and provided theoretical support for the treatment of pain and itch.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2783","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T13:35:05Z","timestamp":1665322505000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Corticotropin\u2010releasing factor is involved in acute stress\u2010induced analgesia and antipruritus"],"prefix":"10.1002","volume":"12","author":[{"given":"Xiao\u2010Dong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Human Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre Air Force Military Medical University  Xi'an China"},{"name":"Department of Emergency Medicine Inner Mongolia Armed Police Corps Hospital  Hohhot China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010Miao","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre Air Force Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Lan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre Air Force Military Medical University  Xi'an China"},{"name":"Department of Human Anatomy, School of Basic Medical Sciences and Forensic Medicine North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin\u2010Fang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre Air Force Military Medical University  Xi'an China"},{"name":"Department of Anatomy Medical School of Yan'an University  Yan'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre Air Force Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen\u2010Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre Air Force Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang\u2010Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, School of Basic Medical Sciences and Forensic Medicine North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9083-7776","authenticated-orcid":false,"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Histology and Embryology and K.K. 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