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The current cross\u2010sectional, between\u2010groups study aimed to quantify symptoms of autonomic dysfunction in a neurodevelopmental pediatric cohort characterized by clinical diagnoses as well as genetic etiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      The Pediatric Autonomic Symptom Scales (PASS) questionnaire was used to assess autonomic features across a group of patients with clinical neurodevelopmental diagnoses (NPD;\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a090) and genetic etiologies. Patients were subdivided based on either having a clinical ASD diagnosis (NPD\u2010ASD;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a037) or other non\u2010ASD neurodevelopmental diagnoses, such as intellectual disability without ASD, speech and language disorders, and\/or attention deficit hyperactivity disorder (NPD\u2010OTHER;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a053). Analyses focused on characterizing differences between the NPD group compared to previously published reference samples, as well as differences between the two NPD subgroups (NPD\u2010ASD and NPD\u2010OTHER).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results indicate higher PASS scores in our NPD cohort relative to children with and without ASD from a previously published cohort. However, we did not identify significant group differences between our NPD\u2010ASD and NPD\u2010OTHER subgroups. Furthermore, we find a significant relationship between quantitative ASD traits and symptoms of autonomic function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This work demonstrates the utility of capturing quantitative estimates of autonomic trait dimensions that may be significantly linked with psychosocial impairments and other core clinical features of ASD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2813","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T17:35:20Z","timestamp":1669311320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Higher scores on autonomic symptom scales in pediatric patients with neurodevelopmental disorders of known genetic etiology"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3724-2551","authenticated-orcid":false,"given":"Antoinette S","family":"DiCriscio","sequence":"first","affiliation":[{"name":"Geisinger Health System Autism &amp; Developmental Medicine Institute (ADMI)  Lewisburg Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KE","family":"Wain","sequence":"additional","affiliation":[{"name":"Geisinger Health System Autism &amp; Developmental Medicine Institute (ADMI)  Lewisburg Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Smith","sequence":"additional","affiliation":[{"name":"Geisinger Health System Autism &amp; Developmental Medicine Institute (ADMI)  Lewisburg Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Beiler","sequence":"additional","affiliation":[{"name":"Geisinger Health System Autism &amp; Developmental Medicine Institute (ADMI)  Lewisburg Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LK","family":"Walsh","sequence":"additional","affiliation":[{"name":"Geisinger Health System Autism &amp; Developmental Medicine Institute (ADMI)  Lewisburg Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Holdren","sequence":"additional","affiliation":[{"name":"Geisinger Health System Autism &amp; Developmental Medicine Institute (ADMI)  Lewisburg Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Troiani","sequence":"additional","affiliation":[{"name":"Geisinger Health System Autism &amp; Developmental Medicine Institute (ADMI)  Lewisburg Pennsylvania USA"},{"name":"Department of Imaging Science and Innovation Center for Health Research, Geisinger  Danville Pennsylvania USA"},{"name":"Neuroscience Institute, Geisinger  Danville Pennsylvania USA"},{"name":"Department of Basic Sciences Geisinger Commonwealth School of Medicine  Scranton Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170868"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1492"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20352"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-013-1920-x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1037\/1089-2680.10.3.229"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.02973.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.11.001"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199705000-00017"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55070346"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00467"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.279"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10802-016-0257-2"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-016-0246-7"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.625564"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.20010015"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2012.04.003"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-017-3193-2"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12064"},{"key":"e_1_2_9_20_1","volume-title":"Encyclopedia of autism spectrum disorders","author":"Constantino J. 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