{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T07:59:10Z","timestamp":1783238350696,"version":"3.54.6"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In acute ischemic stroke (AIS), rapid treatment with intravenous thrombolysis (IVT) is crucial for good clinical outcome. Weekly simulation\u2010based team\u2010training of the stroke treatment team was implemented, resulting in faster treatment times. The aim of this study was to assess whether this time reduction led to a higher proportion of stroke mimics (SMs) among patients who received IVT for presumed AIS, and whether these SM patients were harmed by intracranial hemorrhage (ICH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All suspected AIS patients treated with IVT between January 1, 2015 and December 31, 2020 were prospectively registered. In 2017, weekly in situ simulation\u2010based team\u2010training involving the whole stroke treatment team was introduced. To analyze possible unintended effects of simulation training, the proportion of SMs among patients who received IVT for presumed AIS were identified by clinical and radiological evaluation. Additionally, we identified the extent of symptomatic ICH (sICH) in IVT\u2010treated SM patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 2015 to 2020, 959 patients were treated with IVT for symptoms of AIS. After introduction of simulation training, the proportion of patients treated with IVT who were later diagnosed as SMs increased significantly (15.9% vs. 24.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.003). There were no ICH complications in the SM patients treated before, whereas two SM patients suffered from asymptomatic ICH after introduction of simulation training (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a01.0). When subgrouping SMs into prespecified categories, only the group diagnosed with peripheral vertigo increased significantly (2.5% vs. 8.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Simulation training of the acute stroke treatment team was associated with an increase in the proportion of patients treated with IVT for a suspected AIS who were later diagnosed with peripheral vertigo. The proportion of other SM groups among IVT\u2010treated patients did not change significantly. No sICH was detected in IVT\u2010treated SM patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2814","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T08:56:53Z","timestamp":1669193813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Simulation\u2010based team\u2010training in acute stroke: Is it safe to speed up?"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9311-0476","authenticated-orcid":false,"given":"Liv Jorunn","family":"H\u00f8llesli","sequence":"first","affiliation":[{"name":"Stavanger Medical Imaging Laboratory (SMIL) Department of Radiology Stavanger University Hospital  Stavanger Norway"},{"name":"Department of Electrical Engineering and Computer Science University of Stavanger  Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soffien Chadli","family":"Ajmi","sequence":"additional","affiliation":[{"name":"Neurology Research Group, Department of Neurology Stavanger University Hospital  Stavanger Norway"},{"name":"Department of Quality and Health Technology University of Stavanger  Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin W.","family":"Kurz","sequence":"additional","affiliation":[{"name":"Neurology Research Group, Department of Neurology Stavanger University Hospital  Stavanger Norway"},{"name":"Department of Clinical Medicine University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Bailey","family":"Tysland","sequence":"additional","affiliation":[{"name":"Neurology Research Group, Department of Neurology Stavanger University Hospital  Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Hagir","sequence":"additional","affiliation":[{"name":"Department of Radiology Hospital of Southern Norway Kristiansand  Kristiansand Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingvild","family":"Dalen","sequence":"additional","affiliation":[{"name":"Department of Research Section of Biostatistics Stavanger University Hospital  Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrun Anna","family":"Qvindesland","sequence":"additional","affiliation":[{"name":"Department of Research, Simulation Section Stavanger University Hospital  Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hege","family":"Ersdal","sequence":"additional","affiliation":[{"name":"Critical Care and Anesthesiology Research Group Stavanger University Hospital  Stavanger Norway"},{"name":"Faculty of Health Sciences University of Stavanger  Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathinka D.","family":"Kurz","sequence":"additional","affiliation":[{"name":"Stavanger Medical 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